MRI: Acquisition of a Shared X-ray Diffractometer for Research, Education, and Training

劳伦斯·T. Scott和来自波士顿学院的同事Amir Hoveyda将获得一台单晶X射线衍射仪，以支持多个领域的研究，包括：1）均匀单手性碳纳米管的化学合成; 2）化学合成新催化剂的设计和开发; 3）与光系统II相关的仿生化学; 4）脂质双层中的蛋白质折叠; 5）鉴定新型果糖1，6-二磷酸酶抑制剂; 6）对复杂二苯并呋喃类化合物的不对称合成的研究; 7）用于合成fDNA的稠合核苷（fN）; 8）用于合成的催化二硼化反应; 9）催化支架配体; 10）X射线晶体学推进新的化学方法。单晶X射线晶体学技术允许准确和精确地确定分子的完整三维结构，包括键距和键角，并且它提供关于分子相对于相邻分子的空间排列的准确信息。这些研究将在许多领域产生影响，从合成有机和无机化学到生物系统和材料研究。该仪器将成为教学和研究的一个组成部分。

With this award from the Major Research Instrumentation (MRI) program, Lawrence T. Scott and colleague Amir Hoveyda from Boston College will acquire a single crystal X-ray diffractometer to support research in a variety of areas including: 1) chemical synthesis of uniform, single-chirality carbon nanotubes; 2) design and development of new catalysts for chemical synthesis; 3) biomimetic chemistry relevant to Photosystem II; 4) protein folding in lipid bilayers; 5) identification of new classes of inhibitors of fructose 1,6-bisphosphatase; 6) studies toward the asymmetric synthesis of complex dibenzofuranoids; 7) fused nucleosides (fN) for the synthesis of fDNA; 8) catalytic diboration reactions for use in synthesis; 9) catalytic scaffolding ligands; 10) advancing new chemical methods with X-ray crystallography.The technique of single-crystal X-ray crystallography allows accurate and precise determination of the full three dimensional structure of a molecule, including bond distances and angles, and it provides accurate information about the spatial arrangement of molecules relative to the neighboring molecules. These studies will have an impact in a number of areas ranging from synthetic organic and inorganic chemistry to systems of biological interest and materials research. This instrument will be an integral part of teaching as well as research.