CAREER: Inorganic Nanoparticles with Biological Properties: Preparation, Characterization and Sensing Applications

ID: MPS/DMR/BMAT(7623) 0954919 PI: Andreescu， Emanuela ORG: Clarkson university标题：职业：具有生物特性的无机纳米颗粒：制备，表征和传感应用智力优势：这个职业发展计划的目标是开发和研究一类新的无机仿生材料，重点是基于铈的金属氧化物。该计划旨在促进对与其物理化学性质相关的控制其生物特性的机制的理解，并得出结构-活性关系，以便合理设计基于这些材料的新型传感方法。该研究将为生物材料研究的一个新的、独特的领域提供关键的实验数据，即具有有趣的仿生和储氧能力的无机材料及其在传感中的应用。具体来说，这将是第一次研究基于铈的金属氧化物纳米颗粒（NPs）的酶样活性与其物理化学和结构特征的关系。研究将包括：(1)通过定制合成和系统修饰NPs表面来优化和控制表面反应性；(2)确定调节NPs反应性的关键参数，并利用这些特性来控制其生物活性；(3)测试其酶样？活动和(4)传感应用将利用其特殊的仿生特性，以及它们的储氧能力。更广泛的影响：本研究在生物材料研究领域引入了一个独特的概念，即无机材料模仿传统的生物催化剂，具有氧气储存/释放能力，用于先进的生物医学和传感应用。从这些研究中获得的基础知识将使新一代仿生材料和设备的合理设计在稳定性，稳健性和低氧依赖性方面具有前所未有的性能。除了生物材料和生物传感器之外，这项研究还将影响这些材料可以找到有用应用的各种其他领域（例如，作为灭活活性氧的治疗药物的生物医学，作为需要在极端条件下操作的催化剂的生物技术）。该项目将对课程发展、学生培训、招聘和指导产生重大影响。一个新的高级本科-研究生课程和探究式实验模块将被开发，以提供克拉克森学生的跨学科教育。通过计划中的外展活动，将创建用于动手实验的学习模块和教师支持材料，介绍给当地高中。毕业生和本科生将与教师、高中教师和学生协商，合作准备高中和普通化学版本的拟议实验。实施提高新生留校率的试点项目。该项目将有助于化学系加强生物分子科学项目的努力，并增加和保留克拉克森理科专业的人数。拟议的以探究为基础的实验室单元将提高对现代科学技术的可及性，并提供可转移给其他机构和包括当地高中和社区学院在内的更多学生的材料。通过该项目，通过PI正在进行的项目和已建立的合作项目招募的未被充分代表的少数民族学生将有机会进行独立研究。

ID: MPS/DMR/BMAT(7623) 0954919 PI: Andreescu, Emanuela ORG: Clarkson UniversityTitle: CAREER: Inorganic Nanoparticles with Biological Properties: Preparation, Characterization and Sensing ApplicationsINTELLECTUAL MERIT: The objective of this career development plan is to develop and study a new class of inorganic biomimetic materials, with focus on ceria based metal oxides. The plan is designed to advance understanding of the mechanism that governs their biological properties in relation to their physicochemical properties and to derive structure-activity relations for the purpose of rational design of novel sensing approaches based on these materials. The proposed research will provide key experimental data in a new and unique area of biomaterials research, that of inorganic materials possessing interesting bio-mimetic properties and oxygen storage ability, and of their applications in sensing. Specifically, this will be the first investigation of the enzyme-like activity of ceria based metal oxides nanoparticles (NPs) in relation to their physicochemical and structural characteristics. Research will involve: (1) optimizing and controlling surface reactivity through tailored synthesis and systematic modifications of the NPs surface, (2) identifying key parameters that regulate NPs reactivity and using these properties to control their biological activity, (3) testing their ?enzyme-like? activity and (4) sensing applications that will take advantage of their special biomimetic properties, and their oxygen storage capacity.BROADER IMPACTS: This research introduces a unique concept in the biomaterials research arena, that of inorganic materials mimicking traditional biological catalysts and possessing oxygen storage/release capabilities for advanced biomedical and sensing applications. The fundamental knowledge gained from these studies will enable rational design of a new generation of bio-mimetic materials and devices with unprecedented performance in terms of stability, robustness, and low oxygen dependency. In addition to biomaterials and biosensors, this research will also impact a variety of other fields where these materials could find useful applications (e.g. biomedicine as therapeutic drugs to inactivate reactive oxygen species, biotechnology as catalysts that require operation at extreme conditions). The project will have a major impact on course development, student training, recruitment and mentoring. A new upper level undergraduate-graduate course and inquiry-based laboratory modules will be developed to provide interdisciplinary education of Clarkson students. Learning modules and instructor support materials for hands-on experiments will be created for introduction to local high schools through the planned outreach activities. Graduates and undergraduates will collaborate to prepare high school and general chemistry versions of the proposed experiments in consultation with faculty and high school teachers and students. A pilot program for enhancing retention rates of entering freshmen will be instituted. The project will contribute to the efforts of the Chemistry Department to strengthen the biomolecular science program and increase and retain the numbers of science majors at Clarkson. The proposed inquiry-based laboratory modules will enhance accessibility to modern scientific technologies and provide materials that are transferable to other institutions and to a larger number of students including local high schools and community colleges. Through this program, underrepresented minority students, recruited through on-going programs and established collaborations of the PI, will be provided with an opportunity to conduct independent research.