Scalable Nanomanufacturing of Uniform Inorganic Nanoparticles Using Jet-Mixing Reactors

使用喷射混合反应器大规模纳米制造均匀无机纳米粒子

• 批准号: 2111412
• 负责人: Jessica Winter
• 金额: $ 73.35万
• 依托单位: Ohio State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2111412&HistoricalAwards=false
• 关键词: Scalable; Nanomanufacturing; Uniform; Inorganic; Nanoparticles

Nanoparticles have unique optical, magnetic, electronic, and catalytic properties that could lead to advances in computing, energy storage, chemical manufacturing, and healthcare. However, for those advances to be realized, nanoparticle syntheses must be translated from small laboratory-scale batch processes to commercial scale manufacturing processes. There have been several advances in continuous manufacturing of polymer nanoparticles; however, inorganic nanoparticles (i.e., metals, semiconductors, ceramics) are more difficult to manufacture because they often require high temperatures and inert environments. This award develops a high temperature and/or air-free scalable nanomanufacturing process for inorganic nanoparticles using catalyst and semiconductor quantum dots as model systems. These materials have high commercial potential (market capitalization of more than $1 billion per year) and are applied across industry sectors from healthcare to electronics. These materials have import for national security and global leadership because they are used in new kinds of computing important for American competitiveness, such as spintronics and quantum computing. This work also trains a diverse workforce for emerging careers in scalable nanomanufacturing with input from companies engaging in scale up processes. This research addresses a critical need for scalable processes for manufacturing inorganic nanoparticles. Currently, many of these materials are manufactured in batch processes that limit nanoparticle uniformity, and thus control of their size-dependent properties. Building upon successful polymer nanoparticle synthesis in jet mixing reactors via a nanoprecipitation route, this research develops inorganic (metal, semiconductor) nanoparticle manufacturing in air-free and/or high temperature jet-mixing reactors and provides accompanying scaling laws for their scale-up. As model systems the project studies CdS, MnS, and PbS quantum dots and Cu alloy catalysts, which are oxygen sensitive, require high temperatures for synthesis, or exhibit different morphologies depending on temperature. Concurrently, the project develops methods to integrate jet-mixing reactors in series to enable manufacture of core-shell nanoparticles composed of different materials. Such hybrid materials offer potential for multifunctionality or tunable properties. Currently, hybrid nanoparticles are manufactured in batch systems that are difficult to scale. This work also investigates methods of thermal control using fluid flow (as opposed to external heating and cooling) to enable rapid control in high temperature manufacturing processes. This is accomplished by interdisciplinary interactions within the team of experts in reactor design, nanoparticle synthesis, COMSOL modeling, and nucleation and growth theory. The project advances knowledge in the understanding and control of continuous scalable nanomanufacturing technologies.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

纳米粒子具有独特的光学、磁性、电子和催化特性，可能会导致计算、储能、化学制造和医疗保健领域的进步。然而，为了实现这些进步，纳米颗粒合成必须从小型实验室规模的批量工艺转化为商业规模的制造工艺。在聚合物纳米颗粒的连续制造方面已经有了一些进展;然而，无机纳米颗粒（即，金属、半导体、陶瓷）更难以制造，因为它们通常需要高温和惰性环境。该奖项开发了一种高温和/或无空气的可扩展的纳米制造工艺，用于使用催化剂和半导体量子点作为模型系统的无机纳米颗粒。这些材料具有很高的商业潜力（每年市值超过10亿美元），并应用于从医疗保健到电子产品的各个行业。这些材料对国家安全和全球领导力至关重要，因为它们用于对美国竞争力至关重要的新型计算，如自旋电子学和量子计算。这项工作还为可扩展的纳米制造的新兴职业培训了多样化的劳动力，并从参与规模化过程的公司获得了投入。这项研究解决了制造无机纳米粒子的可扩展过程的关键需求。目前，这些材料中的许多是在批量过程中制造的，这限制了纳米颗粒的均匀性，从而控制了它们的尺寸依赖性。基于在喷射混合反应器中通过纳米沉淀路线成功合成聚合物纳米颗粒，本研究开发了在无空气和/或高温喷射混合反应器中制造无机（金属，半导体）纳米颗粒，并提供了相应的缩放定律。作为模型系统，该项目研究了CdS，MnS和PbS量子点和Cu合金催化剂，这些催化剂对氧敏感，需要高温合成，或根据温度表现出不同的形态。同时，该项目开发了将喷射混合反应器串联起来的方法，以制造由不同材料组成的核壳纳米颗粒。这种杂化材料提供了多功能性或可调性质的潜力。目前，混合纳米颗粒在难以规模化的批量系统中制造。这项工作还研究了使用流体流动（而不是外部加热和冷却）的热控制方法，以实现高温制造过程的快速控制。这是通过反应器设计，纳米颗粒合成，COMSOL建模以及成核和生长理论专家团队内的跨学科互动来实现的。该项目在理解和控制连续可扩展的纳米制造技术方面取得了进步。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。