MRI: Acquisition of a quadrupole time-of-flight mass spectrometer for research and education in the chemical and biological sciences

凭借主要研究仪器（MRI）计划和化学部的这一奖项，瓦萨学院的Teresa加勒特将获得四极杆飞行时间质谱仪（Q-TOF）。 该奖项将加强研究培训和教育，特别是在革兰氏阴性菌中甘油磷脂头基酰化的生物化学研究，在刺胞动物共生建立过程中发生的代谢变化，生物漂白中涉及的酶的生物化学修饰，微生物衍生的生物表面活性剂的结构，孤儿核受体配体的鉴定，以及富勒烯有机反应中间体的表征。 该质谱仪（Q-TOF）将与高分辨率液相色谱系统耦合。 这将液相色谱的物理分离能力与质谱的质量分析能力相结合。液相色谱仪把混合物分离成分子组分。这些成分流入质谱仪，在那里测量它们的质量及其碎片的质量。 Q-TOF质谱仪是一种特殊的设计，可提供高质量精度，灵敏度和分辨率，允许检测和确定复杂混合物中分子的结构。 仪器将提供教师和学生在几个机构，包括瓦萨学院，马里斯特学院，巴德学院和纽约州立大学新帕尔茨，有机会追求研究项目使用现代仪器迄今为止没有在机构。 它还将用于几个实验室课程，以培训大量学生使用这一重要的分析技术。

With this award from the Major Research Instrumentation (MRI) program and the Chemistry Division, Teresa Garrett from Vassar College will acquire a quadrupole time-of-flight mass spectrometer (Q-TOF). The award will enhance research training and education especially in studies of the biochemistry of glycerophospholipid headgroup acylation in Gram-negative bacteria, the metabolic changes that occur during the establishment of symbiosis in Cnidarians, the biochemical modification of an enzyme involved in bio-bleaching, the structure of microbially derived biosurfactants, identification of ligands for orphan nuclear receptors, and characterization of fullerene organic reaction intermediates. This mass spectrometer (Q-TOF) will be coupled to a high-resolution liquid chromatography system. This combines the physical separation capability of liquid chromatography with the mass analysis ability of mass spectrometry. The liquid chromatograph separates a mixture into its molecular components. These components flow into a mass spectrometer where their masses, and those of their fragments, are measured. A Q-TOF mass spectrometer is a special design that provides high mass accuracy, sensitivity and resolution that allows detection and determination of the structure of molecules in a complex mixture. The instrumentation will provide faculty and students in several institutions including Vassar College, Marist College, Bard College, and SUNY New Paltz, the opportunity to pursue research projects using modern instrumentation not heretofore available at the institutions. It will also be used in several laboratory courses to train significant numbers of students in the use of this important analytical technique.