MRI: Acquisition of a Liquid Chromatograph, Quadrupole, Time-of-Flight Mass Spectrometer to Enhance Undergraduate Research and Education in the Chemical and Biochemical Sciences

MRI:购买液相色谱仪、四极杆、飞行时间质谱仪,以加强化学和生物化学科学方面的本科研究和教育

基本信息

  • 批准号:
    2017788
  • 负责人:
  • 金额:
    $ 23.22万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-08-15 至 2023-07-31
  • 项目状态:
    已结题

项目摘要

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. The College of Wooster is acquiring a liquid chromatograph, quadrupole, time-of-flight mass spectrometer (LC-Q-TOF-MS) to support Professor Paul Edmiston and colleague, Jennifer Faust. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species in complex samples. In a typical experiment, the components flow into a mass spectrometer where they are ionized and the ions' masses are measured. This highly sensitive technique allows the structure of molecules in complex mixtures to be studied. An instrument with a liquid chromatograph can separate mixtures of compounds before they reach the mass spectrometer. In the time-of-flight (TOF) method of mass spectrometry, the mass-to-charge ratio of an ion is determined by the way in which ions are accelerated by an electric field of known strength. The acquisition strengthens the research infrastructure at the University and regional area. The instrument broadens participation by involving diverse groups of students in research and research training using this modern analytical technique. It also provides training opportunities to many undergraduate students at this institution and serves as a resource for K-12 hands-on research engagement as well as course-embedded research projects designed to broaden diversity as guided by the STEM Success Initiative at the college. The instrument is also utilized by researchers at nearby institutions such a St Cloud State University, Oberlin College, Kenyon College, Ashland University, and Denison UniversityThe award of the mass spectrometer is aimed at enhancing research and education at all levels. The instrument acquisition impacts identification of pharmaceutical transformation products in human-impacted surface waters. The LC-Q-TOF-MS is used for investigations of anthropogenic compounds in Hawaiian estuaries by a researcher from St Cloud State University. In addition, the mass spectrometer provides information for studying the fate and transport of perfluoroalkyl substances (PFAS) in the environment and exploring multiphase reactions of organic components in rainwater. The mass spectrometer is also used to analyze protein cross-linkers to identify redox partners of protein disulfide isomerases and for studying the factors influencing differential allocation of seminal fluid proteins in the fruit fly, D. melanogaster. Finally, the instrument is utilized to study the metabolic role of arginine kinases in bacteria and the use of unnatural amino acids to generate chromophores for fluorescence imaging.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
该奖项由主要研究仪器项目和化学研究仪器项目支持。伍斯特学院正在购买一台液体色谱仪、四极杆飞行时间质谱仪(LC-Q-TOF-MS),以支持保罗·埃德米斯顿教授和他的同事詹妮弗·福斯特。通常,质谱仪是用于鉴定和表征复杂样品中少量化学物种的关键分析方法之一。在一个典型的实验中,这些成分流入质谱仪,在那里它们被电离,并测量离子的质量。这种高度灵敏的技术使研究复杂混合物中的分子结构成为可能。带有液体色谱仪的仪器可以在混合物到达质谱计之前将其分离。在飞行时间(TOF)质谱学方法中,离子的质荷比是通过离子被已知强度的电场加速的方式来确定的。此次收购加强了该大学和该地区的研究基础设施。该仪器通过让不同的学生群体参与研究和使用这种现代分析技术进行研究培训,扩大了参与度。它还为该学院的许多本科生提供培训机会,并作为K-12实践研究活动的资源,以及在学院STEM成功倡议的指导下旨在扩大多样性的课程嵌入研究项目。该仪器也被附近机构的研究人员使用,如圣克劳德州立大学、奥伯林学院、凯尼恩学院、阿什兰大学和丹尼森大学。质谱仪的获奖旨在加强各级的研究和教育。仪器的获取影响到受人类影响的地表水中药物转化产品的识别。圣克劳德州立大学的一名研究人员使用LC-Q-TOF-MS对夏威夷河口的人为化合物进行了调查。此外,质谱仪还为研究全氟烷基物质(PFAS)在环境中的去向和迁移以及探索雨水中有机成分的多相反应提供信息。该质谱仪还用于分析蛋白质交联物,以确定蛋白质二硫键异构酶的氧化还原伙伴,并研究影响果蝇精液蛋白质差异分配的因素。最后,该仪器被用来研究精氨酸激酶在细菌中的代谢作用,以及使用非天然氨基酸生成荧光成像的发色团。这一奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Suspect screening for pesticides in rain and snow using liquid chromatography high-resolution mass spectrometry
利用液相色谱高分辨质谱法筛查雨雪中农药疑似物
  • DOI:
    10.1016/j.atmosenv.2022.119389
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    5
  • 作者:
    Gray, Rebekah;Painter, Eve;Sprankle, Jameson W.;Crawford, Alex D.;Morrison, Jillian J.;Frazier, Marian;Faust, Jennifer A.
  • 通讯作者:
    Faust, Jennifer A.
Non-targeted identification and semi-quantitation of emerging per-and polyfluoroalkyl substances (PFAS) in US rainwater.
美国雨水中新出现的全氟烷基物质和多氟烷基物质 (PFAS) 的非目标鉴定和半定量。
  • DOI:
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Kim, Yubin;Pike, Kyndal A.;Gray, Rebekah;Sprankle, Jameson W.;Faust, Jennifer A.;and Edmiston;Paul L.
  • 通讯作者:
    Paul L.
Contaminants of Emerging Concern in the Lower Volta River, Ghana, West Africa: The Agriculture, Aquaculture, and Urban Development Nexus
  • DOI:
    10.1002/etc.5279
  • 发表时间:
    2022-01-20
  • 期刊:
  • 影响因子:
    4.1
  • 作者:
    Chester, Anndee Huff;Gordon, Christopher;Schoenfuss, Heiko L.
  • 通讯作者:
    Schoenfuss, Heiko L.
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Paul Edmiston其他文献

Paul Edmiston的其他文献

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{{ truncateString('Paul Edmiston', 18)}}的其他基金

Collaborative Research, RUI: Assessing Load Reduction and Biological Recovery After 500 MGD Treatment Upgrades in an Effluent-Dominated Aquatic Ecosystem
RUI 合作研究:评估以污水为主的水生生态系统中 500 MGD 处理升级后的负荷减少和生物恢复
  • 批准号:
    1336604
  • 财政年份:
    2014
  • 资助金额:
    $ 23.22万
  • 项目类别:
    Standard Grant
SBIR (RAPID):Process Development to Restore Osorb Swelling Glass Fouled While Recovering Gulf Oil-Water Mixtures
SBIR (RAPID):恢复海湾油水混合物时污染的吸收膨胀玻璃的工艺开发
  • 批准号:
    1047699
  • 财政年份:
    2010
  • 资助金额:
    $ 23.22万
  • 项目类别:
    Standard Grant
SBIR Phase I: Produced Water Treatment Using Animated Organosilicas That Rapidly and Reversibly Swell
SBIR 第一阶段:使用快速可逆膨胀的动画有机硅处理采出水
  • 批准号:
    1013263
  • 财政年份:
    2010
  • 资助金额:
    $ 23.22万
  • 项目类别:
    Standard Grant
RUI: Engineering Organosilica Materials that Rapidly and Reversible Swell for Water Remediation
RUI:用于水体修复的快速可逆膨胀的工程有机硅材料
  • 批准号:
    0930371
  • 财政年份:
    2009
  • 资助金额:
    $ 23.22万
  • 项目类别:
    Standard Grant
CAREER: Optical Sensors for the Detection of Vapor Phase Explosives Using Molecularly Imprinted Sol-Gel Materials: Integration of Research and Learning Using Forensic Science
职业:使用分子印迹溶胶-凝胶材料检测气相爆炸物的光学传感器:利用法医科学整合研究和学习
  • 批准号:
    0238808
  • 财政年份:
    2003
  • 资助金额:
    $ 23.22万
  • 项目类别:
    Continuing Grant

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