NSF/FDA Scholar-in-Residence at FDA: Transport in Polymeric Materials used in Biomedical Devices

1041361 elabd该PI建议使用时间分辨傅里叶变换红外衰减全反射（FTIR-ATR）光谱研究用于生物医学设备的聚合物中液体的传输。该技术的独特之处在于，它是一种非侵入性的原位方法，具有鲁棒性、准确性，可以在液体/聚合物系统中提供可靠的早期数据。此外，时间分辨FTIR-ATR光谱提供了扩散剂（例如，水，药物替代品）和聚合物之间的分子水平对比，因为两者的整个中红外光谱都是作为时间的函数在原位测量的。这允许探索扩散剂/聚合物系统中的分子变化（例如，多组分扩散，聚合物弛豫），以及量化扩散剂和聚合物之间分子相互作用的能力。将这种技术用于生物医学设备中聚合物的运输是一个未开发的领域。本研究项目的成果将提供分子水平转运机制的基本理解，并为生物医学设备科学提供新的知识体系。

1041361ElabdThe PI proposes to investigate the transport of liquids in polymers used in biomedical devices with time-resolved Fourier transform infrared-attenuated total reflectance (FTIR-ATR) spectroscopy. This technique is unique in that it is a non-invasive, in situ method that is robust, accurate, and can provide reliable early-time data in liquid/polymer systems.Additionally, time-resolved FTIR-ATR spectroscopy provides molecular-level contrast between diffusant(s) (e.g., water, drug surrogates) and the polymer as the entire mid-infrared spectrum of both are measured in situ as a function of time. This allows for the exploration of molecular changes in the diffusant/polymer system (e.g., multicomponent diffusion, polymer relaxation), and the ability to quantify molecular interactions between diffusants and polymer. Using this technique is an unexplored area for transport in polymers used in biomedical devices. The outcomes of this research project will provide a fundamental understanding of molecular level transport mechanisms and provide a new body of knowledge in biomedical device science.