EAGER:Nanoimaging for Molecular Diagnosis of Retina

1053978MotamediA多学科研究团队来自德克萨斯大学医学分部（UTMB），拥有眼科、视网膜生物化学、先进光学成像和生物医学工程方面的专业知识，与奥本大学的Vainrub博士合作，在纳米成像的超分辨率显微镜技术的开发方面具有专业知识。将开发和测试一种多模态成像系统，用于视网膜病变和创伤性脑损伤等情况引起的视网膜病理的早期检测和监测。多平台成像系统包括自体荧光、共聚焦扫描激光眼科（SLO）、傅立叶域光学相干断层扫描（FDOCT）、自适应光学（AO）和荧光成像，用于多模态组合可以提供具有潜在细胞分辨率的视网膜高分辨率分子图像。SLO、FDOCT和PISRM将用于量化内源性和外源性生物标志物和纳米造影剂的时空分布，这些造影剂被设计用于检测炎症反应作为疾病进展的功能。

1053978MotamediA multidisciplinary team of investigators with expertise in ophthalmology, retinal biochemistry, advanced optical imaging, and biomedical engineering from the University of Texas Medical Branch (UTMB) in collaboration with Dr. Vainrub from Auburn University with expertise in the development of super resolution microscopy technique for nanoimaging, will develop and test a multimodal imaging system for early detection and monitoring of retinal pathology induced by conditions such as retinopathy and traumatic brain injury. Multiplatform imaging system including autofluorescence, confocal scanning laser ophthalmology (SLO), Fourier domain optical coherence tomography (FDOCT), adaptive optics (AO), and fluorescence imaging - used in multimodal combination can provide high resolution molecular images of the retina with potentially cellular resolution. SLO, FDOCT, and PISRM will be used to quantify the spatial and temporal distributions of endogenous and exogenous biomarkers and nano-based contrast agent designed for detection of inflammatory responses as a function of disease progression.