Genomic Approaches in Biotechnology

通过该项目，冷泉港实验室（CSHL）的多兰DNA学习中心（DNALC）与社区大学教师和国家生物技术高级技术教育中心（Bio-Link）合作，正在建立一个专业发展计划，以传播教学模块，为基因组时代的生物技术职业提供坚实的基础。该计划侧重于四个关键技术：聚合酶链反应（PCR），DNA测序，RNA干扰（RNAi）和生物信息学。 它包括三个真核系统：人类，植物和蠕虫。每个模块都可以集成到现有课程中，为新课程提供基础，或作为学生研究项目的基础。智力优势：后基因组时代要求生物技术人员配备所需的工具和智力，以挖掘隐藏在复杂和动态的真核生物基因组中的巨大潜力。这一建议的智力价值在于它为该领域带来了一个新的视角，这是一种基于真核生物的方法，适用于高中和大学生的基因组学实验室。 评估计划涉及斯托尼布鲁克的纽约州立大学的教师和博士生，该计划既有项目本身的优点，也有项目为梳理教师发展努力的成果而建立的模型的优点，这些成果涉及随后的教师活动和由此产生的学生成果。一个强大的社区学院的观点，包括程序开发和行业合作的最佳实践，补充了实验计划。在为期三年的任期内，该计划将在全国12所社区学院举行为期一周的研讨会，涉及288名生物技术教师。12个社区学院顾问的领导干部参与该计划的各个方面：确定研讨会课程，主办和共同教学研讨会，提供参与者后续支持，评估该计划在课堂上的影响，并传播该项目。其他专家顾问来自生物技术行业，高中和4年制大学。广泛的课堂实施得到了为每个教学模块建立的互联网网站、开发的定制生物信息学工具、从不同供应商处获得的教学工具包以及将由CSHL出版社出版的实验室文本《基因组科学》的支持。

With this project, the Dolan DNA Learning Center (DNALC) of Cold Spring Harbor Laboratory (CSHL), in collaboration with community college faculty and the National Advanced Technological Education Center for Biotechnology (Bio-Link) is establishing a professional development program to disseminate instructional modules that provide a strong foundation for biotechnology careers in the genome age. The program focuses on four key technologies: polymerase chain reaction (PCR), DNA sequencing, RNA interference (RNAi), and bioinformatics. It encompasses three eukaryotic systems: humans, plants, and nematode worms. Each module can be integrated into existing courses, provide the basis for new courses, or serve as the foundation for student research projects. Intellectual Merit: The post-genome era demands biotechnicians equipped with the tools and intellect needed to tap the enormous potential hidden within complex and dynamic eukaryotic genomes. The intellectual merit of this proposal lies in the fact it brings a new perspective to the field, a cost effective eukaryote based approach to high school and undergraduate laboratories in genomics. The evaluation plan, involving faculty and doctoral students at the State University of New York at Stony Brook, has merits both for the project itself and for the model it establishes for teasing out the outcomes of faculty development efforts as regards subsequent faculty activity and the resultant student outcomes.Broader Impacts: A strong community college perspective, including best practices for program development and industry collaborations, complements the experimental program. Over its three-year term, the program will reach 288 biotechnology faculty at week-long workshops conducted at 12 community colleges nationwide. A leadership cadre of 12 community college advisors is involved in all aspects of the program: determining workshop curriculum, hosting and co-teaching workshops, providing participant follow-up support, evaluating the program impact in the classroom, and disseminating the project. Additional expert advisors are drawn from the biotechnology industry, high schools, and 4-year colleges. Broad classroom implementation is supported by the Internet sites built for each teaching module, the custom bioinformatics tools developed, the teaching kits available from various suppliers, and a laboratory text, Genome Science, to be published by CSHL Press.