Collaborative Research: The Hybrid Integration of Plasmonic Interferometer Sensors and Active Optoelectronic Devices on a Single Microfluidic Chip

该计划的目标是通过在单个微流控芯片上混合集成无源等离子体干涉仪和硅波导阵列耦合的有源光电器件来创建一个高度集成的传感器系统，用于低成本、实时、无标签、无透镜和多路复用的传感应用。该设备提供了一种紧凑和便携的检测解决方案，用于医疗诊断，目前还不存在，但对于克服传统角度可调的棱镜表面等离子体共振系统的尺寸和成本障碍至关重要。其智能优点是将芯片级半导体光源和探测器与等离子体传感器集成在一块芯片上，因此光不需要耦合到/出传感器进行分析。垂直等离子体干涉仪将通过在单一波长下的强度询问来执行传感功能。弯曲硅波导被用来连接有源光电子器件和等离子体干涉仪，并通过阻止未耦合的光进入探测器来提高传感器的性能。还将研究获得温度引起的信号漂移的芯片上消除的新方法。更广泛的影响是研究芯片规模的一体式传感器平台，并将研究和教育相结合。拟议的研究结果将对生物传感、医疗保健和国家需求产生巨大的长期影响。教育和外展计划的主要目标是加强绩效指标？本科实验室课程，提高研究生和本科生对纳米光子学和生物光子学前沿研究的参与度，并为科学、技术、工程和数学学科中代表性不足的群体提供机会。

The objective of this program is to create a highly integrated sensor system through hybrid integration of passive plasmonic interferometers and Si waveguide array coupled active optoelectronic devices on a single microfluidic chip for low cost, real-time, label-free, lens-free, and multiplexed sensing applications. The proposed device provides a compact and portable sensing solution for point-of-care diagnostics that does not currently exist but is critical for overcoming size and cost barriers of conventional angular-tunable, prism-based surface plasmon resonance systems.The intellectual merit is to integrate chip-scale semiconductor light sources and detectors with plasmonic sensors on a single chip so that light does not need to be coupled into/out of the sensors for analysis. Vertical plasmonic interferometers will perform the sensing function through intensity interrogation at a single wavelength. Curved silicon waveguides are proposed to interconnect active optoelectronic devices and plasmonic interferometers and enhance the sensor performance by preventing uncoupled light from entering the detector. Novel methods to obtain on-chip cancellation of temperature-induced signal drift will also be investigated.The broader impacts are to investigate chip-scale all-in-one sensor platforms and integrate research and education. The outcome of the proposed research will have enormous long-term impacts on biosensing, health care and the national needs. The main goals of the education and outreach program are to enhance the PIs? undergraduate laboratory courses, improve the participation of graduate and undergraduate students in cutting-edge research in nanophotonics and biophotonics, and provide opportunities for under-represented groups in science, technology, engineering, and mathematics disciplines.