Chiral NMR Shift Reagents

在这项由化学系化学测量和成像计划资助的奖项中，贝茨学院的托马斯·温泽尔教授和他的本科生研究人员将被支持合成和表征新型手性核磁共振位移试剂。温泽尔教授和他的学生创造的试剂种类将使化学家能够快速确定新合成化合物的对映体纯度。手性分子是具有手性对称性的分子。它们在结构上的不同只是在某种意义上它们是彼此的镜像。由于它们具有相同的化学结构，除了它们的利手性外，很难或不可能使用像核磁共振这样的分析技术来评估这些化合物混合物的对映体纯度。温泽尔教授和他的学生对设计试剂感兴趣，这些试剂将与不同的光学异构体在不同程度上相互作用，这将导致不同异构体的核磁共振谱不同。这项工作在药物分析中有重要的应用。从事这一项目的本科生将在进行这些感兴趣的分子的物理化学表征方面获得有用的经验，并为进一步学习化学科学做好准备。

In this award, funded by the Chemical Measurement and Imaging Program of the Division of Chemistry, Professor Thomas Wenzel of Bates College and his undergraduate student researchers will be supported to synthesize and characterize new kinds of chiral NMR shift reagents. The kinds of reagents that Prof. Wenzel and his students create will enable chemists to rapidly determine the enantiomeric purity of newly synthesized compounds.Chiral molecules are molecules that have "handed" symmetry. They differ in structure from each other only in the sense that they are mirror images of each other. Since they have identical chemical structures, except for their handedness, it is difficult or impossible to use analytical techniques like NMR to assess the enantiomeric purity of mixtures of these compounds. Professor Wenzel and his students are interested in designing reagents that will interact with different optical isomers to different extent, which will cause differences in the NMR spectra for the different isomers. This work has important applications in the analysis of pharmaceuticals. The undergraduate students working on this project will gain useful experience in carrying out the physico-chemical characterization of these interesting molecules, and they will be prepared for further study in the chemical sciences.