MOSFET-embedded Microcantilever-based Multiplexed Sensor Platform for Continuous Physiological Monitoring of Biomolecular Interactions

具有所需灵敏度、特异性和工程约束的生物分子物种传感对许多领域至关重要；从有毒物种的环境监测到个性化健康诊断。这样一个可行的传感器系统的多样化和多重考虑需要跨学科的方法，结合生物结合事件的固有特异性，广泛部署的信号转导平台以及必要的经济，人体工程学和系统级约束。鉴于对多样化和多方面方法的需求，国际合作对于促进我们对生化传感多路集成传感器阵列的理解至关重要。生物工程传感器的研究需要大量的设备工程模拟、过程迭代和高水平的实验室实验，而西北大学（NU）和巴塞尔大学（UB）拥有大量的互补资源和专业知识。这个OISE合作项目将汇集美国和瑞士的研究人员来解决生物分子传感的关键需求。该项目利用了伊利诺斯州埃文斯顿国立大学和瑞士巴塞尔UB大学的个人小组中现有的强大的基于悬臂的传感器研究活动。该项目旨在开发使用简单、成本效益高、可广泛部署的传感器系统，并适用于对许多技术至关重要的各种生物分子物种的大规模并行（多路复用）检测。从环境监测到个人健康指标。这些包括dna、蛋白质和病毒病原体；为例。拟议的合作将为科学家和学生提供各自机构无法获得的设施和专业知识。国际合作还将帮助各行业在涉及多路传感器技术应用的领域雇用训练有素的人员。通过西北大学和巴塞尔大学之间的OISE国际合作项目的共同努力，将为生物分子传感器的开发和应用奠定基础，这种基于硅的检测平台具有相当大的前景，可以作为一种点对护理、手持式、具有成本效益和广泛部署的检测系统。

Sensing of biomolecular species with required sensitivity, specificity and engineering constraints is critical to numerous fields; ranging from environmental monitoring of toxic species to personalized health diagnostics. The diverse and multiple considerations for such a viable sensor system require interdisciplinary approach that combines the innate specificity of biological binding events, a signal transduction platform that is widely deployable and the necessary economic, ergonomic and systems-level constraints. Given such needs for diverse and multifaceted approaches, international collaborations are essential to advancing our understanding of multiplexed integrated sensor arrays for biochemical sensing. Bio-engineered sensors research requires numerous device engineering simulations, process iterations and high-level laboratory experimentation in which Northwestern (NU) and University of Basel (UB) have substantial complementary resources and expertise. This OISE collaborative project will bring together US and Swiss researchers to address the critical needs in biomolecular sensing. The project leverages strong existing cantilever-based sensors research activities in individual groups at NU in Evanston, IL and UB at Basel, Switzerland. The project aims to develop sensor systems that are simple-to-use, cost effective, widely deployable, and amenable to massively parallel (multiplexed) detection of diverse biomolecular species that are critical to many technologies ? ranging from environmental monitoring to personal health markers. These would include DNAs, proteins and viral pathogens; for example. The proposed collaboration will provide scientists and students access to facilities and expertise not available at respective individual institutions. The international collaboration will also help industries to engage highly-trained personnel in fields involving applications of multiplexed sensor technologies. The collective effort through this OISE international collaborative program between Northwestern and Basel will set the stage for biomolecular sensor development and applications using silicon-based detection platform that has considerable promise as a point-to-care, handheld, cost-effective and widely deployable detection system.