CIF: Small: Fast In Vivo Optical Imaging in the Heavily and Weakly Scattering Regimes

普渡大学凯文·韦伯（kevin Webb）：光学成像在医学中很重要，因为它提供了关于人类健康的独特信息，并为实验室、临床和家庭使用的廉价便携式仪器提供了途径。在深层组织光学扩散断层扫描框架内，确定血液化学监测和了解疾病的化学和分子信息成为可能。研究更快和更准确的深层组织成像是促进光学在医学研究和治疗中更广泛应用的关键一步。体内光学成像的另一个重要挑战是进入皮肤几毫米范围内的状态，例如应用于皮肤癌。这项研究涉及到一种方法的发展，该方法描述了这种近表面长度尺度上的光学组织特性，从而为成像提供了基础。总的来说，这项工作将在癌症的早期检测、术中成像以确保所有肿瘤结节在手术中被切除以及血液化学监测等应用中发挥重要作用。更具体地说，描述散射和吸收、荧光和荧光共振能量转移参数的各种光学扩散层析成像模式正在开发中。该方法通过使用激光身体扫描来定义几何形状和基于扩散方程的非结构化网格正演模型，避免了受试者放置的背景散射乳液。在这项工作中，多重网格方法与非结构化网格相结合，可以实现快速准确的成像。在弱散射条件下，一种基于贝特-萨尔皮特方程的成像方法正在开发，该方法使用空间和频率上的严格场相关。

ABSTRACTCIF: Small: Fast In Vivo Optical Imaging in the Heavily and Weakly Scattering RegimesKevin Webb, Purdue UniversityOptical imaging is important in medicine because it provides unique information about human health and an avenue for inexpensive and portable instruments for laboratory, clinical and home use. Within a deep-tissue optical diffusion tomography framework, it becomes possible to determine chemical and molecular information for blood chemistry monitoring and understanding diseases. The research on faster and more accurate deep-tissue imaging is a critical step in facilitating more widespread use of optics in medical research and for treatment. Another important challenge for in vivo optical imaging is access to the regime within a few millimeters of the skin, with application to skin cancer, for example. This research involves the development of a method that describes optical tissue properties on this near-surface length scale and hence provides a basis for imaging. Collectively, this work will be important in applications like the early detection of cancer, intra-operative imaging to ensure all tumor nodules are removed during surgery, and blood chemistry monitoring.More specifically, various optical diffusion tomography modalities describing scatter and absorption, fluorescence, and fluorescence resonance energy transfer parameters are being developed. The approach avoids a background scattering emulsion, in which the subject is placed, by use of a laser body scan to define the geometry and an unstructured mesh forward model based on the diffusion equation. In this work, a multigrid method coupled to the unstructured mesh permits fast and accurate imaging. In the weakly scattering regime, an imaging method based on the Bethe-Salpeter equation that uses a rigorous field correlation over space and frequency is being developed.