The genetics of ageing in human populations

该项目旨在测试个体之间的遗传差异是否会影响晚年认知和生理功能的变化。个体之间的差异，在他们的生理变化方面，随着年龄的增长，导致他们对负面晚年结果的易感性差异，并最终导致寿命的差异。利用基因组技术，新的数据分析方法和同类最大的数据集的组合，该项目旨在确定与这些变化相关的基因组区域和生化途径，并测试早期生殖和晚年结果之间的遗传关联。这对于理解、预测和管理人类不同生命阶段的过渡至关重要。

This project aims to test whether genetic differences among individuals influence changes in cognition and physiological function in later life. Differences among individuals, in terms of distinct changes in their physiology as they age, lead to differences in their susceptibility to negative later-life outcomes and ultimately to differences in lifespan. Using a combination of genomic techniques, novel data analysis methods, and the largest dataset of its kind, the project intends to identify the genomic regions and biochemical pathways associated with these changes, and to test for genetic associations between early-life reproduction and later-life outcomes. This is crucial to understanding, predicting and managing transitions across different human life stages.