Mouse models for the identification of factors involved in muscle adaptation

肌肉适应功能需求的能力对于日常生活、衰老、肌肉疾病和神经损伤患者以及运动员的活动能力至关重要。肌肉改变其细胞组成的能力对畜牧业是可取的。了解肌肉细胞中的基因是如何调节以适应需求的，对公共卫生和经济效益具有重大意义。我们设计了模型系统，使我们能够识别这些基因的调节因子，从而开发出对抗衰老和受损肌肉变化的疗法，提高肉类质量，优化运动表现。

The ability of muscle to adapt to meet functional demands is essential for mobility in normal daily life, in ageing well, in individuals with muscle diseases and nerve damage and in athletes. The ability of muscle to change its cellular composition is desirable for the livestock industry. Knowledge of how genes in muscle cells are regulated to adapt to demands has significant implications for public health and economic benefits. We have devised model systems that will allow us to identify the regulators of these genes in order to develop therapies to combat these changes in ageing and damaged muscle, to improve the quality of meat and optimise sport performance.