Divergent Catalysis for Metal Carbene Reactions

在这个由化学系化学合成计划资助的项目中，德克萨斯大学圣安东尼奥分校的Michael Doyle教授正在研究催化生成的金属卡宾作为构建复杂有机化合物的合成工具。 这项研究为金属卡宾的形成和反应提供了催化方面的基本进展，并为准备从事化学科学职业的学生的教育提供了研究机会。 该研究计划包括增加多样性的举措，特别是通过西班牙裔和非洲裔美国学生的更多参与，以及本科生参与研究。 正在努力培养一个国际财团，以研究金属卡宾生成和反应的化学催化中关键的未解决的问题。 正在研究使用卡宾前体的催化方法，这些方法在产物形成方面具有立体控制和多样性。Doyle教授致力于开发给体-受体环丙烯作为有效的卡宾前体。该研究提供了具有不同反应活性的催化剂，并提高了分子内金属卡宾加成的立体选择性。该研究拓宽了范围，并扩大了通过金属卡宾中间体发生的化学转化的多功能性。

AbstractIn this project funded by the Chemical Synthesis program of the Chemistry Division, Professor Michael Doyle of the University of Texas at San Antonio is investigating catalytically generated metal carbenes as synthetic tools for the construction of complex organic compounds. This research provides fundamental advances in catalysis for metal carbene formation and reactions and offers research opportunities for the education of students who are preparing for careers in the chemical sciences. The research program includes initiatives to increase diversity, particularly through greater participation of Hispanic and African American students, and undergraduate participation in research. Efforts are undertaken to cultivate an international consortia to investigate critical unsolved problems in chemical catalysis for metal carbene generation and reactions. Catalytic processes using carbene precursors that operate with stereocontrol and diversity in product formation are under investigation. Professor Doyle is pursuing the development of donor-acceptor cyclopropenes as effective carbene precursors. The research provides catalysts with divergent reactivities and that improve the stereoselectivity in intramolecular metal carbene additions. The research broadens the scope and expands the versatility of chemical transformations that occur through metal carbene intermediates.