UNS:Parylene-in-Parylene (PiP) integrated photonic systems for optogenetics in microelectrocorticography (uECoG)

主要研究者：Maharbiz，MichelProposal：1512794植入式生物光子装置在体内传感、成像和光遗传神经刺激等应用中需求量很大。研究人员建议设计，制造和表征完全由Parylene构建的紧凑，灵活和生物相容的光子结构。 他们将把这种波导与开关和光源集成在一起，以实现一个完全可重构和集成的光子平台。全聚对二甲苯光子平台从未发表过。这种创新将产生直接影响，因为Parylene通常用于超柔性植入式系统。需要生物相容性和柔性的集成光子结构，其在用于慢性应用时不会降解、分层或分开。柔性光子学的最新进展主要依赖于将导波器件转移到柔性衬底上来实现异质伪柔性光子器件。这样的实现容易退化并且故障仅适用于短期诊断植入。拟议的研究引入了一个新的平台，用于实现紧凑和灵活的集成光子器件，利用已经开发良好的生物相容性材料系统用于封装生物器件。 该方案包括一个精心构思的外联活动计划。

PI: Maharbiz, MichelProposal: 1512794Implantable biophotonic devices are highly in demand for applications such as in-vivo sensing, imaging, and optogenetic neural stimulation. The researchers propose to design, fabricate, and characterize compact, flexible, and biocompatible photonic structures built entirely from Parylene. They will integrate such waveguides with switches and light sources to realize a fully reconfigurable and integrated photonic platform. An all-Parylene photonic platform has never been published. Such an innovation would have immediate impact as Parylene is routinely used in ultra-flexible, implantable systems. Biocompatible and flexible integrated photonic structures are required that do not degrade, delaminate, or fall apart when used in chronic applications. Recent advances in flexible photonics mostly rely on transferring guided-wave devices to a flexible substrate to realize heterogeneous pseudo-flexible photonic devices. Such implementations are vulnerable to degradation and failure are only suitable for short-term diagnostic implants. The proposed research introduces a new platform for realizing compact and flexible integrated photonic devices leveraging an already well-developed biocompatible material system used for encapsulating biodevices. This program includes a well-conceived plan for outreach activities.