Trapping and Watching Biomolecular Complexes near Nanopores

该项目旨在开发一种技术来捕获和询问纳米级分子复合物的自然状态。水中纳米级复合物提供了生物系统的核心机制，需要对其进行详细的了解，以帮助揭示基本的生物机制。已经开发出一种方法的原型，可以在纳米孔装置中捕获和询问小至190纳米的纳米级物体。通过开展研究以充分理解、小型化和进一步发展这种方法，该项目旨在对涉及细胞间通信和DNA展开的纳米级生物机制进行定量观察。这种技术平台可以应用于生物学、生物技术和先进材料等领域。

This project aims to develop a technology to trap and interrogate nanosized molecular complexes in their natural state. Nanosized complexes in water provide the core machinery of biological systems and require detailed understanding to help unravel fundamental biological mechanisms. A prototype of a methodology has been developed to trap and interrogate nanoscaled objects as small as 190 nanometres within a nanopore device. By performing research to fully understand, miniaturise and develop this method further, this project aims to enable the quantitative observation of nanoscaled biological machinery involved in cell-to-cell communication and DNA unfolding. Such a technology platform may have applications in areas such as biology, biotechnology and advanced materials.