MRI: Acquisition of a 400 MHz NMR Spectrometer for Chemistry and Chemical Forensics

在主要研究仪器（MRI），化学研究仪器（CRIF）和EPSCoR计划的支持下，来自罗得岛大学的Brenton DeBoef教授及其同事William Euler，Jimmie奥克斯利，Brett Lucht和Geoffrey Bothun将获得400 MHz NMR光谱仪。该光谱仪将允许在各种领域进行研究，例如加速具有重要经济意义的化学反应，以及允许研究生物相关物种。一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为本科生和研究生进行教学和研究的一个组成部分。拟议仪器的其他更广泛的影响将通过对高级化学学生使用最先进仪器的实践培训，URI化学相关研究和教育的持续增长以及URI化学与其社区之间的外联来实现，包括举办年度全州高中化学竞赛，该奖项旨在加强各级研究和教育，特别是在以下领域，如（a）理解区域选择性氧化交叉偶联通过C？H活化;（B）研究用于超极化氙-129磁共振成像的隐吩衍生分子探针;（c）发现使用荧光光谱法检测爆炸物的新的灵敏方法;（d）更好地了解锂电池中的反应;（e）研究有机催化开环聚合过程;（f）研究巴氏梭菌在粗甘油发酵过程中的适应性;（g）研究工程纳米颗粒与生物膜之间的相互作用;以及（h）合成有机大环化合物。

With this award supported by the Major Research Instrumentation (MRI), the Chemistry Research Instrumentation (CRIF), and EPSCoR programs, Professor Brenton DeBoef from University of Rhode Island and colleagues William Euler, Jimmie Oxley, Brett Lucht and Geoffrey Bothun will acquire a 400 MHz NMR spectrometer. This spectrometer will allow research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research performed by undergraduate and graduate students. Additional broader impacts of the proposed instrument will be realized by the hands-on training of advanced chemistry students in the use of state-of-the-art instrumentation, the continued growth of chemistry-related research and education at URI, and the outreach between URI Chemistry and its community, including the hosting of an annual, state-wide High School Chemistry contest, and an annual Chemistry Camp for junior high girls.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) understanding regioselective oxidative cross-coupling via C?H activation; (b) studying cryptophane-derived molecular probes for hyperpolarized Xenon-129 magnetic resonance imaging (MRI); (c) discovering new and sensitive methods for the detection of explosives using fluorescence spectroscopy; (d) developing a better understanding of reactions in lithium batteries; (e) investigating organocatalytic ring-opening polymerization (ROP) processes; (f) studying Clostridium pasteurianum adaptation during crude glycerol fermentation; (g) investigating interactions between engineered nanoparticles and biological membranes; and (h) synthesizing organic macrocycles.