Divergent Catalysis for Metal Carbene Reactions

在这个由化学系化学合成计划资助的项目中，德克萨斯大学圣安东尼奥分校的迈克尔·道尔教授正在研究催化生成的金属卡宾作为构建复杂有机化合物的合成工具。这项研究提供了金属卡宾形成和反应的催化方面的基本进展，并为准备从事化学科学职业的学生的教育提供了研究机会。该研究计划包括增加多样性的举措，特别是通过增加西班牙裔和非裔美国学生的参与，以及本科生参与研究。正在努力建立一个国际联盟，研究金属卡宾生成和反应的化学催化中尚未解决的关键问题。使用卡宾前体的催化过程正在调查中，这些过程的操作具有立体控制和产物形成的多样性。多伊尔教授正在致力于开发供体-受体环丙烯作为有效的卡宾前体。本研究提供了具有发散反应活性的催化剂，并提高了分子内金属卡宾加成的立体选择性。这项研究拓宽了通过金属卡宾中间体发生的化学转化的范围和多样性。

AbstractIn this project funded by the Chemical Synthesis program of the Chemistry Division, Professor Michael Doyle of the University of Texas at San Antonio is investigating catalytically generated metal carbenes as synthetic tools for the construction of complex organic compounds. This research provides fundamental advances in catalysis for metal carbene formation and reactions and offers research opportunities for the education of students who are preparing for careers in the chemical sciences. The research program includes initiatives to increase diversity, particularly through greater participation of Hispanic and African American students, and undergraduate participation in research. Efforts are undertaken to cultivate an international consortia to investigate critical unsolved problems in chemical catalysis for metal carbene generation and reactions. Catalytic processes using carbene precursors that operate with stereocontrol and diversity in product formation are under investigation. Professor Doyle is pursuing the development of donor-acceptor cyclopropenes as effective carbene precursors. The research provides catalysts with divergent reactivities and that improve the stereoselectivity in intramolecular metal carbene additions. The research broadens the scope and expands the versatility of chemical transformations that occur through metal carbene intermediates.