Cellular response to pro-oxidative myoglobin

心脏很容易受到氧化损伤，因为被称为肌细胞的特殊肌肉细胞无法再生。对心肌细胞的氧化损伤会降低细胞活力，进而降低心肌功能。促氧化形式的肌红蛋白存在于心脏中，可能在损伤肌细胞中起作用。这项研究将确定一系列新的合成抗氧化剂是否能抑制肌红蛋白介导的心肌损伤并保持功能。这可能导致对抗心血管疾病的新疗法，并使澳大利亚老年人能够保持富有成效和独立的生活方式。

The heart is vulnerable to oxidative damage as specialised muscle cells termed myocytes are unable to regenerate. Oxidative damage to myocytes decreases cell viability and in turn heart muscle function. Pro-oxidative forms of the protein myoglobin are present in the heart and may play a role in damaging myocytes. This study will determine whether a series of novel synthetic antioxidants inhibit myoglobin-mediated damage to heart muscle and preserve function. This may lead to new therapies to combat cardiovascular disease and enable ageing Australians to maintain productive and independent lifestyles.