MRI: Acquisition of High-Sensitivity, Solids Capable 400 MHz NMR for Research and Undergraduate Training at the University of Colorado at Denver

该奖项由主要研究仪器（MRI）和化学研究仪器（CRIF）项目支持。科罗拉多大学丹佛市中心校区的Scott Reed教授和他的同事Liliya Vugmeyster获得了一台400兆赫的固态核磁共振光谱仪。该光谱仪允许在各种领域的研究，如那些加速具有重要经济意义的化学反应。总的来说，核磁共振波谱是化学家研究分子结构最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液或固体状态下分子之间相互作用的变化。获得最先进的核磁共振光谱仪对进行前沿研究的化学家很重要。这些核磁共振研究的结果对合成有机/无机化学、材料化学、法医学和生物化学都有影响。该仪器是教学和研究的一个组成部分，本科生通过独立的学生研究和传统的学术课程，以及研究人员和硕士生进行研究。该光谱仪被用于几个项目，以满足代表性不足的少数民族人口的需求。例如，科罗拉多大学本科生暑期项目（CUSP）、多元文化学生研究生体验（GEMS）、神经科学研究成果（BRAiN）、暑期本科生研究奖学金、LabCoats、科学增强研究计划（RISE）、最大化研究职业机会（MARC U-STAR）、学生癌症研究奖学金和暑期本科生少数民族转化科学指导（SUMMiT）。这种核磁共振光谱仪增强了各级的研究和教育。这可能会影响光释放脂质探针的制备，修饰RNA的结构-功能关系的研究，以及用于肿瘤体内光学成像的近红外自发光纳米颗粒的探索。该仪器还用于研究钙抑制C2结构域的结构机制，探索界面相互作用在南极土壤中未冻结水存活中的作用，以及研究蛋白质动力学转变的机制性质。该光谱仪有助于研究脂质相互作用对淀粉样蛋白- β原纤维内部动力学的影响，液晶弹性体的相变，以及固态14-氮和17-氧核磁共振对天然有机物的应用。

This award is supported by the Major Research Instrumentation (MRI) and the Chemistry Research Instrumentation (CRIF) Programs. Professor Scott Reed from University of Colorado Denver-Downtown Campus and colleague Liliya Vugmeyster have acquired a 400 MHz nuclear magnetic resonance (NMR) spectrometer with solid state capabilities. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance. In general, NMR spectroscopy is one of the most powerful tools available to chemists for studying the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the changes in interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is important to chemists who are carrying out frontier research. The results from these NMR studies have an impact in synthetic organic/inorganic chemistry, materials chemistry, forensics and biochemistry. This instrument is an integral part of teaching as well as research performed by undergraduate students via independent student research and traditional academic coursework as well as researchers and master's students. The spectrometer is used by several programs that cater to underrepresented minority populations. Examples are Colorado Undergraduate Summer Program (CUSP), Graduate Experiences for Multicultural Students (GEMS), Building Research Achievement in Neuroscience (BRAiN), Summer Undergraduate Research Fellowship, LabCoats, Research Initiative for Scientific Enhancement (RISE), Maximizing Access to Research Careers (MARC U-STAR), Student Cancer Research Fellowship and Summer Undergraduate Minority Mentoring in Translational Science (SUMMiT).This NMR spectrometer enhances research and education at all levels. It may impact research efforts on the preparation of photo-releasable lipid probes, studies of structure-function relationships of modified RNA, and exploration of near-infrared self-illuminating nanoparticles for in vivo optical imaging of tumors. The instrumentation is also used for studying structural mechanisms of calcium inhibited C2 domains, exploring the role of interfacial interactions in the survival of unfrozen water in Antartic soils, and studying the mechanistic nature of protein dynamics transitions. The spectrometer benefits investigations on the effects of lipid interactions on internal dynamics of amyloid-beta fibrils, on phase transitions in liquid-crystalline elastomers, and on applications of solid state 14-nitrogen and 17-oxygen NMR to natural organic matter.