MRI: Acquisition of a Nuclear Magnetic Resonance (NMR) Spectrometer for Research and Training at Central Michigan University

该奖项由主要研究仪器和化学研究仪器计划支持。中密歇根大学正在购买一台500 MHz核磁共振（NMR）光谱仪，配有自动样品加载器和温度控制系统，以支持Benjamin Swarts博士及其同事Anja Mueller，Janice Tomasik，Choon Y Lee和Wenjun Du的研究。该光谱仪可以在各种领域进行研究，例如加速具有重要经济意义的化学反应，以及允许化学和生物学相关物种的研究。一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。该仪器是该机构化学和生物化学专业本科生和研究生以及区域社区学院合作者的教学、研究和研究培训的一个组成部分。授予NMR光谱仪的目的是加强各级的研究和教育。它特别影响了碳水化合物/脂质合成的研究，创造了研究细菌的化学工具，并产生了基于多糖的可再生材料。该仪器还用于搜索从树枝状聚合物获得的抗氧化剂材料，并表征用于合成基于聚合物（包括多糖）的燃料电池和皮肤支架的产品。此外，它允许表征聚合一氧化氮释放架构和氧化还原酶机制的探索。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Central Michigan University is acquiring a 500 MHz nuclear magnetic resonance (NMR) spectrometer equipped with an automatic sample loader and a temperature control system to support research of Dr. Benjamin Swarts and colleagues Anja Mueller, Janice Tomasik, Choon Y Lee and Wenjun Du. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as permitting study of chemically and biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument is an integral part of teaching as well as research and research training of undergraduate and graduate students in chemistry and biochemistry at this institution as well as collaborators from regional community colleges.The award of the NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts studies of carbohydrate/lipid synthesis, creating chemical tools to study bacteria and generating polysaccharide-based renewable materials. The instrumentation is also used to search for antioxidant materials obtained from dendrimer and characterizing products for the synthesis of polymer (including polysaccharide)-based fuel cells and skin scaffolds. In addition, it allows the characterization of polymeric nitric oxide release architectures and exploration of redox enzyme mechanisms. The instrument also serves researchers creating polymer/dendrimer-based materials.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.