MRI: Acquisition of a 400 MHz NMR Spectrometer for Research and Education

该奖项由主要研究仪器和化学研究仪器项目支持。北伊利诺伊大学正在购买一台400兆赫核磁共振（NMR）光谱仪，以支持Evgueni Nesterov教授及其同事Narayan Hosmane， Ralph Wheeler， Douglas Klumpp和Timothy Hagen的研究。该光谱仪允许在各种领域进行研究，例如那些加速具有重要经济意义的化学反应的领域，以及允许对化学和生物学相关物种进行研究。总的来说，核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液或固体状态下分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。该仪器是该机构化学和生物化学本科生和研究生以及区域主要本科院校合作者的教学、研究和研究培训的一个组成部分。核磁共振光谱仪的奖励旨在加强各级的研究和教育。它尤其影响到有机合成方法的发展以及过渡金属和超酸性催化反应的研究。该仪器还用于有机光化学的基础研究以及用于蛋白质结合的小分子配体的设计和研究。此外，它还允许开发酶抑制剂荧光筛选的分析平台，并研究半导体聚合物材料和先进双功能有机发光二极管（OLED）化合物的受控制备方法。该仪器还为开发环境友好的工业相关催化过程和反应以及设计基于寡核苷酸的分子开关的研究人员提供服务。采用核磁共振波谱仪对用于中子俘获治疗的合成硼碳笼状化合物进行了表征。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Northern Illinois University is acquiring a 400 MHz nuclear magnetic resonance (NMR) spectrometer to support research of Professor Evgueni Nesterov and colleagues Narayan Hosmane, Ralph Wheeler, Douglas Klumpp and Timothy Hagen. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as permitting study of chemically and biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument is an integral part of teaching as well as research and research training of undergraduate and graduate students in chemistry and biochemistry at this institution as well as collaborators from regional primarily undergraduate institutions.The award of the NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts studies developing synthetic organic methodology and transition metal and super-acid catalyzed reactions. The instrumentation is also used for fundamental studies in organic photochemistry and the design and study of small-molecule ligands for protein binding. In addition, it allows the development of an analytical platform for fluorescent screening of enzyme inhibitors and studies on the methods of controlled preparation of semiconducting polymer materials and advanced dual-function organic light-emitting diode (OLED) compounds. The instrument also serves researchers developing environmentally friendly industrially relevant catalytic processes and reactions and those designing oligonucleotide-based molecular switches. The NMR spectrometer is employed in the characterization of synthesized boron-carbon cage compounds which are used in neutron-capture therapy.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.