Intelligent scaffolds and methods for repair of osteochondral defects

骨关节炎（OA）产生骨对骨的关节连接，导致极度疼痛和残疾。在所有肌肉骨骼疾病中，骨关节炎在全世界范围内具有最大的社会和经济影响。到2030年，预计9.3%的成年人将患有关节炎，严重影响他们的生活质量和整体生产力。一种能够修复骨软骨缺损的组织工程产品，不需要随着时间的推移进行翻修，而是与宿主组织完全整合，将具有显著的益处。它将改善患者的活动和生活质量，并显着降低目前与骨关节炎患者相关的医疗费用。

Osteoarthritis (OA) produces articulation of bone against bone resulting in extreme pain and disability. Of all musculoskeletal disorders, osteoarthritis has the greatest social and economic implications worldwide. By 2030, it is projected that 9.3% of the adult population will suffer from arthritis, significantly affecting their quality of life and overall productivity. A tissue engineered product capable of repairing osteochondral defects that does not require revision over time but becomes fully integrated with the host tissue will have significant benefits. It will improve patient activity and quality of life, and significantly reduce current health care costs associated with osteoarthritis sufferers.