Conference: SICB 2023 Symposium: Large-scale phenomena arising from small-scale biophysical processes

该奖项部分资助了参加综合与比较生物学学会(SICB)2023年1月年会的研讨会和研讨会的与会者的费用。这次研讨会聚集了生物学家和工程师，他们研究在不同研究系统中出现的单细胞大规模影响的问题。尽管单个细胞体积很小，但它们的组织和行为方式可能会产生意想不到的广泛影响。例如，细胞之间存在的物理力驱动组织的形成，并为复杂的多细胞生物体的进化铺平道路。从单细胞行为中产生大规模模式的另一个非常不同的例子是单细胞藻类的游泳；游泳帮助它们在海洋环境中导航，并形成从太空中可见的巨大群落。在11位演讲者和2位研讨会组织者中，6位来自科学界代表性不足的团体，9位是职业生涯早期的调查人员；演讲者将介绍和讨论最新的发现和技术，结合最先进的领域、实验室和数学方法。研讨会的主题跨越了生物体的规模和类型，并通过实验和建模解决了生理和生物力学问题。还将举办一个辅助性讲习班，讨论成功开展跨学科研究的战略，以促进利用数学、物理和工程工具解决生物问题。会议和研讨会的结果将发表在学会期刊《综合与比较生物学》上。从单细胞的小规模行为和生理中出现大规模模式是跨多个生物学领域的研究兴趣的广泛主题。为了促进专业知识的交流和促进跨学科研究，本次研讨会将汇集研究人员，他们致力于研究水生和陆地系统中细胞、生物和进化尺度上的生物物理过程。研讨会的三个主要主题是1)小规模生物力学如何塑造组织形成；2)小规模生物物理学如何塑造生态互动；3)物理力量如何塑造早期生命的进化。作为2023年1月在德克萨斯州奥斯汀举行的综合与比较生物学学会年会的一部分，本次研讨会突出了来自不同背景的早期职业研究人员的工作。除了研究报告外，组织者还将主办一个关于跨学科研究最佳做法的研讨会。研讨会和研讨会的结果将通过发表在《综合与比较生物学》杂志上发布，与会者将就这一跨学科领域的未来方向撰写一份立场文件。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award partially supports expenses for participants in a symposium and a workshop at the January 2023 annual meeting of the Society for Integrative and Comparative Biology (SICB). The symposium brings together biologists and engineers studying questions about emerging large-scale influences of single cells in different study systems. Single cells, despite their small size, can organize and behave in ways that have unexpected and wide-reaching consequences. For instance, the physical forces that exist between cells drive tissue formation and pave the way for the evolution of complex, multicellular organisms. Another very different example in which large-scale patterns emerge from individual-cell behavior lies in the swimming of single-celled algae; swimming helps them navigate the ocean environment and form vast communities visible from space. Of the eleven speakers and two symposium organizers, six are from groups underrepresented in science and nine are early-career investigators; the speakers will present and discuss the latest findings and techniques, marrying state-of-the-art field, laboratory, and mathematical approaches. The symposium topic integrates across scales and types of organisms, and addresses both physiological and biomechanical questions through experiments and modeling. There will also be a complementary workshop to discuss strategies for engaging in successful cross-disciplinary research to promote the use of mathematics, physics and engineering tools to address biological problems. Results from the meeting and workshop will be published in the Society’s journal, Integrative and Comparative Biology.The emergence of large-scale patterns from small-scale behavior and physiology of single cells is a broad theme of research interest across multiple biological fields. Aiming to facilitate the exchange of expertise and to promote cross-disciplinary research, this symposium will bring together researchers working on biophysical processes across cellular, organismal, and evolutionary scales in both aquatic and terrestrial systems. The three main themes of the symposium are 1) how small-scale biomechanics shape tissue formation; 2) how small-scale biophysics shape ecological interactions; and 3) how physical forces shape the evolution of early life. As a part of the annual meeting of the Society for Integrative and Comparative Biology in Austin, TX, in January 2023, this symposium highlights the work of early-career researchers from diverse backgrounds. In addition to research presentations, the organizers will host a workshop on best practices in cross-disciplinary research. Results from the symposium and workshop will be disseminated via publication in an issue of the journal Integrative and Comparative Biology, and the participants will produce a position paper about future directions in this interdisciplinary field.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.