Surface engineering of carrier-free drug nanoparticle toward highly efficient anticancer drug delivery

表面修饰策略被仔细监测，以获得具有增强药物递送效率的药物纳米颗粒(化学。中华医学杂志，2017,25 (2):1555-1558；摩尔。克丽丝。液体,克丽丝。（2022年出版）。在脂质体膜修饰药物纳米颗粒制备中，采用SN-38药物纳米颗粒模型体系对膜泡进行连续挤压，实现了在药物纳米颗粒表面的包衣。得到的修饰药物纳米颗粒尺寸稍大，DLS证实其尺寸分布较窄。通过荧光和扫描电镜图像成功地证实了纳米颗粒表面的脂质体层。除了增强在生理环境中的分散稳定性外，我们还表明，脂质体膜层可以进一步修饰，以提供具有特定癌症靶向和荧光成像能力的药物纳米颗粒。优化后的方案将用于药物纳米颗粒与天然来源（如红细胞、白细胞和癌细胞）的脂质体膜的修饰。

Surface modification strategies were carefully monitored to achieve drug nanoparticles with enhanced drug delivery efficiency (Chem. Lett. 2021, 50, 1555-1558; Mol. Crys. Liq. Crys., in press 2022). For the preparation of liposomal membrane modified drug nanoparticles, the coating on the drug nanoparticle surface was achieved by the sequential extrusion of membrane vesicle with the SN-38 drug nanoparticles model system. The modified drug nanoparticles were obtained in a slightly larger size, with narrow size distribution as confirmed by DLS. The liposomal layer on the nanoparticle’s surface was successfully confirmed by fluorescence and SEM images. In addition to the enhanced dispersion stability in the physiological environment, we have also shown that the liposomal membrane layer can be further modified to provide drug nanoparticles with specific cancer targeting and fluorescence imaging capability. The optimized protocol will be employed for the modification of drug nanoparticles with the liposomal membrane derived from natural sources such as red blood cells, white blood cells, and cancer cells.