Investigation of soy protein isolate in whole body glucose metabolism
Investigation of soy protein isolate in whole body glucose metabolism
批准号:
24650487
负责人:
INOUE Hiroshi
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
大豆分离蛋白(SPI)被认为可以改善胰岛素抵抗。因此,我们测量了以酪蛋白或大豆分离蛋白为主要蛋白质来源的高脂饲料喂养4周后小鼠的全身糖代谢参数。在饲喂酪蛋白-HF饮食和SPI-HF饮食的小鼠之间,体重、血糖水平和血浆胰岛素水平没有差异。饲养4周后,进行糖耐量试验,评价两组大鼠的全身糖耐量,发现两组大鼠的糖耐量无明显差异。这些结果表明,在4周HF喂养条件下,SPI对改善胰岛素抵抗的作用不大。
英文摘要
Soy protein isolate (SPI) is known to improve insulin resistance. Therefore, we measured parameters of whole body glucose metabolism in mice fed with high fat (HF) diet containing casein or SPI as main protein source for 4 weeks. Between mice fed with casein-HF diet and with SPI-HF diet, there is no difference in body weight, blood glucose levels, and plasma insulin levels. At 4 weeks after the initiation of HF feeding, we performed glucose tolerance test to evaluate whole body glucose tolerance between these two group and found no difference of glucose tolerance in these two groups. These findings suggested thatSPI has little effect to improve insulin resistance under the condition of 4 week HF feeding.
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ヒスチジンは、中枢神経を介してインスリン作用による肝糖産生抑制を増強する
组氨酸通过中枢神经系统通过胰岛素作用增强对肝葡萄糖产生的抑制
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[木村久美, 松本道宏, 春日雅人, 井上啓]
通讯作者:
井上啓
DOI:
10.1007/s00125-013-2879-z
发表时间:
2013-06
期刊:
DIABETOLOGIA
影响因子:
8.2
作者:
[Lee, Y. -S., Sasaki, T., Kobayashi, M., Kikuchi, O., Kim, H. -J., Yokota-Hashimoto, H., Shimpuku, M., Susanti, V. -Y., Ido-Kitamura, Y., Kimura, K., Inoue, H., Tanaka-Okamoto, M., Ishizaki, H., Miyoshi, J., Ohya, S., Tanaka, Y., Kitajima, S., Kitamura, T.]
通讯作者:
Kitamura, T.
DOI:
10.1007/s00125-013-2849-5
发表时间:
2013-05
期刊:
DIABETOLOGIA
影响因子:
8.2
作者:
[Asahara, S., Shibutani, Y., Teruyama, K., Inoue, H. Y., Kawada, Y., Etoh, H., Matsuda, T., Kimura-Koyanagi, M., Hashimoto, N., Sakahara, M., Fujimoto, W., Takahashi, H., Ueda, S., Hosooka, T., Satoh, T., Inoue, H., Matsumoto, M., Aiba, A., Kasuga, M., Kido, Y.]
通讯作者:
Kido, Y.
第4回「食」による生活習慣病予防医学の展開シンポジウム「食と肝糖産生の制御」
第四届通过食物预防生活方式相关疾病研讨会:“食物与肝葡萄糖生成的控制”
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[松尾陽香, 岩本綾香, 大塚剛司, 秋月さおり, 青木麻実, 古瀬充宏, 安尾しのぶ, Asahara S, 安尾しのぶ, 吉村美紀, 井上啓]
通讯作者:
井上啓
DOI:
10.2337/db12-1701
发表时间:
2013-07
期刊:
Diabetes
影响因子:
7.7
作者:
[Kimura K, Nakamura Y, Inaba Y, Matsumoto M, Kido Y, Asahara S, Matsuda T, Watanabe H, Maeda A, Inagaki F, Mukai C, Takeda K, Akira S, Ota T, Nakabayashi H, Kaneko S, Kasuga M, Inoue H]
通讯作者:
Inoue H
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