Identification and functional characterization of anandamide receptors in Caenorhabditis elegans as a model organism.

大麻素是内源性大麻素的一种，参与多种生理过程。CB 1、CB 2和TRPV在哺乳动物中作为大麻素受体。此外还 哺乳动物有一个未知的大麻素受体CBx。为了鉴定新的大麻素受体，我们以秀丽隐杆线虫为模型进行了功能筛选 有机体因此，我们成功地鉴定了新的线虫七跨膜受体，命名为SFAH-1和SFAH-2。SFAH-1显示与CB 1和CB 2受体的弱相似性，而SFAH-2显示与CB 1和CB 2受体的弱相似性。 类似于某种脊椎动物的肽受体。

Anandamide, a member of endocannabinoids, is known to be involved in manyphysiological processes. CB1, CB2 and TRPV act as anandamide receptors in mammals. In addition, it has been suggested that mammals have an unidentified receptor CBx for anandamide. To identify new anandamide receptors, we performed a functional screening by using a nematode Caenorhabditis elegans as a model organism. As a result, we successfully identified new nematode seven-transmembrane receptors, designated as SFAH-1 and SFAH-2. SFAH-1 shows a weak similarity to CB1 and CB2 receptors, whereas SFAH-2 shows a similarity to a certain kind of vertebrate peptide receptor.