A patho-physiological study on perinatal abnormalities in NC/Tnd mice

NC/Tnd小鼠作为自发性模型在世界范围内被广泛用于特应性皮炎的研究，但繁殖困难，存在妊娠晚期产妇死亡和分娩时新生儿死亡的情况。然而，原因尚不清楚。羊水栓塞对围产期母亲的身体有严重的影响，导致患者出现过敏症状。因此，在本研究中，我们重点研究了NC/Tnd小鼠的围产期异常，并检测了小鼠在妊娠期间的免疫状态。结果血中过敏毒素和血小板活化因子浓度均高于标准小鼠。结果表明，妊娠NC/Tnd小鼠的Th1免疫应答可能涉及围产期注意到的异常。

NC/Tnd mice are widely used for a study on atopic dermatitis as a spontaneous model all over the world, but breeding is difficult and there are some maternal death in the third pregnancy trimester and newborn baby death at the time of the delivery. However, the cause has been unclear. The amniotic fluid embolism which has a serious influence on a perinatal mother's body brings the anaphylactic condition of a patient. Therefore, in this study, we focused on perinatal abnormality occurred in NC/Tnd mice and examined immune status of the mice during pregnancy. As a result, the blood concentration of anaphylatoxin and the platelet activating factor was higher than the standard mice. Results indicate that the Th1 immune responses in pregnant NC/Tnd mice may involve in abnormalities that are noticed during the perinatal period.