Pathogen eradication mediated by receptor for IgM natural antibody

天然IgM抗体识别各种病原体成分，有助于根除病原体。 我们发现，缺乏IgM Fc受体，Fca/mR（CD 351）的小鼠，表现出减少炎症细胞因子的生产对脂多糖（LPS）和改善生存对脓毒性休克。 我们还发现，边缘区B细胞（MZB），高表达Fca/mR，在很大程度上有助于炎症细胞因子的生产对LPS。因此，Fca/mR调节MZB的炎性细胞因子产生，导致LPS诱导的脓毒性休克期间全身炎症反应的调节。

Natural IgM antibody recognizes various pathogen components and contributes to eradication of pathogens. We found that mice lacking IgM Fc receptor, Fca/mR (CD351), showed reduced inflammatory cytokines production against lipopolysaccharide (LPS) and improved survival against septic shock. We also found that marginal zone B cells (MZBs), highly expressing Fca/mR, largely contribute inflammatory cytokines production against LPS. Thus, Fca/mR regulates inflammatory cytokine production from MZB, leading to the regulation of systemic inflammatory responses during LPS-induced septic shock.