Novel molecular-targeting prevention of cancer by inducers of MMP-8 release

TRAIL是一种能够诱导癌细胞凋亡的细胞因子，对癌症的预防有重要作用。我们发现基质金属蛋白酶8 （matrix metalloproteinase 8, MMP-8）是负责TRAIL释放的关键因子之一，我们已经证明丁酸菌促进MMP-8的释放并诱导中性粒细胞内源性TRAIL的释放（国际医学杂志，2013,42:903）。因此，我们假设可以通过检测TRAIL上调释放MMP-8的因子来寻找预防癌症的食物因子。然后，我们对各种候选成分进行筛选，例如具有免疫刺激作用的成分。然而，与丁酸菌相比，没有发现有足够效果的候选菌。

TRAIL is cytokine which can induce apoptosis against cancer cells, and has contributed to cancer prevention. We found that matrix metalloproteinase 8 (MMP-8) is one of the key factors responsible for the release of TRAIL, and we have shown that butyric acid bacterium promotes the release of MMP-8 and induces the release of endogenous TRAIL from neutrophils (Int J Oncol, 2013, 42:903).We therefore hypothesized that we could find the cancer preventive food factors by detecting factors to release MMP-8 with up-regulation of TRAIL. We then performed a screening for a variety of candidates such as the ingredients with immunostimulatory action. However, the candidate with sufficient effect was not found as compared with the butyric acid bacterium.