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Induction of immune-tolerance by a novel human trophoblast-specific soluble factor, laeverin

Induction of immune-tolerance by a novel human trophoblast-specific soluble factor, laeverin
新型人类滋养层特异性可溶性因子 laeverin 诱导免疫耐受
批准号:
24659730
负责人:
FUJIWARA Hiroshi
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012 至 --

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中文摘要
翻译
在人类胎盘形成过程中,绒毛外滋养层细胞侵入母体子宫内膜,重建螺旋动脉。在这项研究中,我们研究了一种新的人类滋养层细胞特异的可溶性因子,我们确定的拉韦林的生理作用。我们发现,可溶性莱维林可诱导单核细胞分化为树突状细胞,并可能通过与人类白细胞抗原G协同作用参与诱导免疫耐受。这些发现为人类胎儿宫内发育的机制提供了新的见解。
英文摘要
During human placentation, extravillous trophoblast invades maternal endometrium and remodels spiral arteries. In this study, we examined the physiological roles of a novel human trophoblast-specific soluble factor, laeverin that we identified. We found that soluble-form laeverin induced differentiation of monocytes into dendritic cells and showed possible involvement of laeverin in induction of immune-tolerance in cooperation with HLA-G. These findings provide a new insight into the mechanisms for intrauterine human fetal development.
期刊论文(11)
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科研奖励(0)
会议论文
Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell.
TEX101(一种潜在的新型癌症标记物)在头颈鳞状细胞中过度表达。
DOI: --
发表时间: 2013
期刊: Cancer Biomark
影响因子: 3.1
作者: [Yoshitake H, Yokoi H, Ishikawa H, Maruyama M, Endo S, Nojima M, Yoshida K, Yoshikawa H, Suzuki F, Takamori K, Fujiwara H and Araki Y]
通讯作者: Fujiwara H and Araki Y
月経時の子宮内膜修復過程において、血小板は子宮内膜上皮のintegrityを増強させる
血小板在月经期间子宫内膜修复过程中增强子宫内膜上皮的完整性
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [杉並 興, 佐藤幸保, 堀江昭史, 松本久宣, 谷 洋彦, 藤原 浩, 小西郁生]
通讯作者: 小西郁生
DOI: 10.1097/igc.0b013e3182849e36
发表时间: 2013-03-01
期刊: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
影响因子: 4.8
作者: [Fujiwara, Hiroshi, Nishioka, Yoshihiro, Konishi, Ikuo]
通讯作者: Konishi, Ikuo
DOI: 10.3233/cbm-130302
发表时间: 2012-01-01
期刊: CANCER BIOMARKERS
影响因子: 3.1
作者: [Yoshitake, Hiroshi, Yokoi, Hidenori, Araki, Yoshihiko]
通讯作者: Araki, Yoshihiko
共 7 条
    Room and High Temperature Strength of Harmonic Structured Composite with Almina Dispersed Ti-Al and Titanium
    Studies on Algorithms for Generalized Tree Construction Problems
    Induction of tissue remodeling of reproductive organs using gligl stem cell-derived factors
    • 批准号:
      23659778
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2011
    • 负责人:
      FUJIWARA Hiroshi
    • 依托单位:
    Development of High Hardness and Toughness Materials by Harmonic Microstructure Control
    • 批准号:
      23560847
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.41万
    • 财政年份:
      2011
    • 负责人:
      FUJIWARA Hiroshi
    • 依托单位:
    海外基金