Ion mobility spectrometry coupled to chip-based electrochromatography

该项目的核心动机-离子迁移率光谱与基于芯片的电色谱相结合-是为了开发一种新的分析工具，使复杂样品的快速和高灵敏度分析成为可能。将电驱动小型化色谱与离子迁移率光谱相结合，将高效的液相分离和高灵敏的气相离子检测相结合，将成为一种新型的离子检测系统。与其他联用技术如高效液相色谱/质谱仪相比，电色谱和离子迁移光谱分析都不需要精密的辅助设备，如便于现场或便携使用的泵。研究的重点是开发合适的微流控芯片接口技术，重点是一种新型的漂移管离子迁移率光谱仪，它具有反转的电极性和与电喷雾电离互补的可选的化学气相电离。

The core motivation of the project -Ion mobility spectrometry coupled to chip-based electrochromatography- is the development of a novel analytical tool that enables fast and highly sensitive analysis of complex samples. By fusing electrically driven miniaturized chromatography with ion mobility spectrometry a system combining the desirable features of the two techniques namely high efficiency liquid phase separations and highly sensitive ion detection in the gas phase is to be developed. In contrast to other hyphenated techniques like HPLC/MS, both electrochromatography and ion mobility spectrometry do not require elaborate secondary equipment like pumps which facilitates on-site or portable use of the system. The research focus is on developing of appropriate microfluidic chip interface technology with emphasis on a novel drift tube ion mobility spectrometer with inverted electrical polarity and optional chemical gas phase ionization complementary to electrospray ionization.