DEVELOPMENT OF AN APPARATUS FOR MEASURING TISSUE BLOOD FLOW BY HEAT CLEARANCE CURVE

对于体表循环的定量动态评估，我们开发了包含Peltier堆栈的Proven，并使其能够进行测量。然而，当环境温度变化较大时，这种方法已经不可能对组织血流进行定量的评估。因此，为了改进在任何条件下连续测量组织血流量的仪器，研制了新的探头，并利用热清除曲线对手指进行了人体皮肤血流量测量的基础研究。得到的结果如下：1)测量了导热系数与人体皮肤相近的不同材料板材的导热系数曲线梯度。观察到材料的视网膜电导率与其梯度之间存在高度正相关。新的探头使我们能够定量地评估组织的热裂曲线的梯度。2)它的梯度与…平行地逐渐减小充气止血带引起的手指缺血较多，提示该梯度随手指血流量的变化而变化，其基线是分散的。3)吸氢清除法测得的手指血流量与热割裂曲线的梯度呈高度正相关。利用该系统对振动通行费作业工人静息状态下的外周循环功能进行了研究，并对冷水浸泡过程中及冷水浸泡后的外周循环运动进行了检测。将使用振动工具的工人分为两组：无症状组和雷诺现象组。无症状组手指血流变化表现为冷血管反应，而雷诺现象组手指血流变化不明显。该系统可用于解释其孤雌生殖发生。较少

For the quantative dynamic assessment of body surface circulation, we developed the prove incorporating a peltier stack and enabled its measutement. However, when the environment temperature is chenged largely, if has been impossible to assess tissue blood flow Uantitatively by this method. Therefore, in order to modify the apparatus for measuring tissue blood flow continuously under any condition, new probe was developed and the fundamental studies abour the measutement of human skin blood flow were carried out in the finger using the heat clearance curve. The results obtained were as follows.1) The gradient of heat clearance curvr on plates of various materials similar in the thermal conductivity to human skin was measuted. A highly positive cottrlation between the retmal conductivity of the material and their gradients was observed. New probe enables us to assess the gradient of heat cleatrance curve of tissues queatitatively.2) Its gradient gradually dectrased in parallel with the … More finger ischemia induced by inflation of a tourniguet, suggersting that the gradient varied with the change os finger blood flow and that its baseline was strady.3) A highly significant positive correlation was obtained between finger blood flow measured by the inhaled hydrogen clearance nethod and the gradient of heat cleatance curve. Accordingly, the absolute value of skin blood flow can be measured continuously and invasively in hymans.Using this systems, the peripheral circulatory function of workers who used vibrating tolls were studied at rest, and then the perepheral circulatory movements during and after cold water immersion were examined. Workers using vibration tools were devided into two groups;group with no sympton and group with Ranaud's phenomenon. The changes of finger blood flow of the group with no symptom showed cold vasuclar reaction, but those of the group with Raynaud's phenomenon did not show the reaction clearly. The newly developed system was useful in the elucidataion if its parhogenesis. Less