400 MHz NMR-Konsole

为了满足“Bebeblätter zur Forschung”中描述的项目对核磁共振光谱分析的更高要求(以及勒维中心德鲁伊内的其他项目)，将购买一个光谱仪控制台、一个灵敏的多核探头和一个大容量的样品转换器。新的采集不仅将增加样品容量，特别是能够测量非常低浓度的样品，扩展对杂核的测量，以及通过19F核磁共振光谱分析来确定蛋白质动力学。研究项目的目标包括开发针对被忽视的热带疾病(如血吸虫病)、寄生虫病、高致病性病毒和细菌的活性物质，以及设计和合成甲基转移酶、丝氨酸蛋白酶、纤溶酶和基质金属酶的选择性抑制剂。进一步的目的是表征酶的热力学和结合动力学参数，以及确定配体结合过程中的构型重排。此外，还开展了生物传感器的开发，洋葱属含硫次生代谢物的鉴定，以及真菌生物合成潜力的发现和对其次生代谢的研究。

In order to meet the increased requirements on the nmr spectroscopy due to the projects described in ´Beiblätter zur Forschung´ (amongst others within the LOEWE center DRUID), a spectrometer console, a sensitive multicore probe head and a high-capacity sample changer shall be purchased. The new acquisition will not only increase the sample capacity but in particular enable the measurement of samples with very low concentration, the expansion of measurements of hetero nuclei as well as the determination of protein dynamics by means of 19F nmr spectroscopy. The aims of the research projects comprise the development of active substances against neglected tropical diseases (e.g.schistosomiasis), parasitic diseases, highly pathogenic viruses and bacteria, as well as design and synthesis of selective inhibitors of methyl transferase, serine proteases, of plasmin and matriptase. Further aims are the characterization of thermodynamic and binding kinetic parameters of enzymes as well as the determination of the rearrangement of configuration during ligand binding. Furthermore, the development of biosensors, the identification of sulfur-containing secondary metabolites of the genus Allium, as well as the discovery of the biosynthetic potential of fungi and the investigation of their secondary metabolisms are pursued.