Structural analysis of membrane proteins using template-mediated crystallization

一项新的前沿技术将以膜蛋白系统结晶管道的形式开发出来。这种高通量单层模板技术特别适合于确定蛋白质的结构，否则这些蛋白质很难结晶，具有明显的商业潜力。膜蛋白结构本身对生物技术和制药业的靶向药物设计具有价值，可以通过新的医疗疗法和减少副作用的形式实现好处。单层模板技术还将扩展国家冷冻-EM设施的能力，其基础设施对所有澳大利亚研究人员开放。

A new frontier technology will be developed in the form of a systematic crystallization pipeline for membrane proteins. This high throughput monolayer template technology is particularly suited for the structure determination of proteins that are otherwise difficult to crystallize and has clear commercial potential. Membrane protein structures are themselves of value to the biotechnology and pharmaceutical industry for targeted drug design, which could realise benefits in the form of novel medical treatments and reduced side effects. The monolayer template technology will also extend the capabilities of the National Cryo-EM facility, the infrastructure of which, is open for all Australian researchers.