A study on Non-invasive Multifunctional Measurements of Circulatry Parameters Using Bio-electrical and Photo-plethysmography Techniques

当今时代，随着人口老龄化的加速，对心脏病、动脉硬化和中风等心血管疾病的早期诊断和治疗的需求越来越大。为此，需要一种能够定量评估循环参数的简单和方便的仪器。非侵入性测量具有疼痛和/或损伤小的优点，在临床上更可取。以最少的传感技术同时测量生理参数也将更适合筛查测试和家庭护理使用，这将带来巨大的社会贡献。这项研究的目的是提供一种新的无创、同时进行生理测量的简单技术，基于我们的创新血压计-Pr-…更明显的是，取得了以下重大成果。(1)将VO或VC方法和ADM技术相结合，提出了一种新的同时测量血压、心输出量、外周血管阻力和其他重要心血管参数的方法。为了准确、可靠地检测生物电导纳信号，设计了一种新的四极体积钳方法。(2)用红外光体积描记仪和基于VO法的ADM技术定量测量血容量变化，成功地评价了人体四肢的Arlcrial弹性性质与血压的关系。(3)在VO法的基础上，设计了一种测量动脉血和静脉血血压和血氧分光光度的新技术。(4)提出了一种多功能同时测量人体四肢血压、血流量、动、静脉弹性、红细胞压积、毛细血管压、毛细血管滤过率等参数的电导纳-袖套法。利用这种方法，在运动测试中，从外周循环调节的角度，非侵入性地揭示了几个生理发现。(5)进一步的发展，如长期动态心血管测量，已成功地用于临床和家庭护理，获得了传统方法无法获得的相当重要和有趣的生理发现。通过这些研究，本项目将在生物医学工程的许多领域做出重大贡献，为心血管血流动力学的无创测量和分析提供一个实用的多功能系统。较少

The present era, with accelerated aging of the population, has an increased need for early diagnosis and treatment of cardiovascular diseases such as heart disease, arteriosclerosis and cerebral apoplexy. For this purpose, there has been a requirement for simple and convenient instrumentation capable of quantitative evaluation of circulatory parameters. Non-invasive measurements which inflict little pain and/or injury are preferable in clinical use. Simultaneous measurement of physiological parameters with the least number of sensing techniques will also be more desirable for screening tests and home care use as well, which will provide an achievement of great social contribution. This research project conducted with such aims to provide a new simple technique for non-invasive and simultaneous physiological measurements based on our innovative sphygmomanometry called "volume-oscillometric(O) and volume-compensation (VC) method" and electrical admittance plethysmography(ADM) proposed pr … More eviously, and following significant results were successfully obtained. (1) A new simultaneous measurement of blood pressure,cardiac output,peripheral vascular resistance,and other important cardiovascular parameters has been proposed in combination of the VO or VC method and the ADM technique. A tetra-polar volume-clamp method has been newly designed for accurate and reliable detection of bio-electrical admittance signal. (2) Arlcrial elastic property in the human limbs has been successfully assessed as a function of blood pressure by measuring quantitavely blood volume changes with an infra-red photo-plethysmography and the ADM technique based on the VO method. (3) A new technique has been designed for the measurement of blood pressure as well as oxygenation of arterial and venous blood using a spectro-photometry based on the VO method. (4) An electrical admittance-cuff method has been newly proposed for the multifunctional and simultaneous measurement of blood pressure, blood flow, arterial and venous elasticity, haematocrit, capillary pressure, capillary filtration coefficient and so on in human limbs. With this method, several physiological findings were non-invasively revealed during exercise testing in terms of regulation of peripheral circulation. (5) Further developments such as long-term ambulatory cardiovascular measurements have been successfully progressed for clinical and home care use, obtaining considerably significant and interesting physiological findings which could not be got by conventional methods. Through these investigations, the present project would serve quite significant contributions in many fields of biomedical engineering, providing a practical multifunctional system for the non-invasive measurement and analysis of cardiovascular haemodynamics. Less