Peripheral circulatory dynamics under artificial circulation

本研究旨在通过动物实验，探讨人工循环对外周循环动力学的影响。人工循环包括心室辅助装置、全人工心脏、无搏动泵、静脉-动脉或静脉-静脉转流等循环支持系统。外周循环通过血流动力学参数、血液化学（如儿茶酚胺）、彩色微球法测量的组织血流量、激光多普勒组织血流量计和皮肤温度图的变化进行评价。非搏动性体循环不影响外周循环动力学，外周血管的血管运动得到良好的维持。肺循环的去极化也没有受到显著影响。血液在肺腹侧和背侧之间的分布没有改变，肺含水量也没有改变。从循环控制方面来看，心输出量和外周血管阻力之间的相关性显示为负，外周阻力是控制循环的重要因素，即使在具有人工循环的动物中也是如此。

The purpose of this study is to clarify the influences of artificial circulation on peripheral circulatory dynamics in animal experiments. The artificial circulation includes ventricular assist device, total artificial heart, nonpulsatile pump, veno-arterial or veno-venous bypass and other circulatory support systems. Peripheral circulation was evaluated by changes in hemodynamic parameters, blood chemistry such as catecholamine, tissue blood flow measured by the colored-microsphere method and laser-doppler tissue blood flowmeter and thermography of the skin. Nonpulsatile systemic circulation did not affect peripheral circulatory dynamics and vasomotion of the peripheral vessels was well maintained. Depulsation of the pulmonary circulation was not significantly influenced, either. The distribution of the blood didn't change between ventral and dorsal portion of the lung and lung water content did not alter at all. From the aspect of circulatory control, correlation between cardiac output and peripheral vascular resistance revealed to be negative and peripheral resistance is an important factor to control the circulation even in an animal with an artificial circulation.