Small radius artificial blood vessel with a high endothelial reorganization effect by static magnetic stray field from ferrite coating

研究了在人工血管内壁涂覆铁氧体涂层所需的基本知识；铁氧体涂层的渗漏通量有望促进血管内皮细胞的重组，从而抑制血栓。将膨化聚四氟乙烯(EPTFE)薄膜置于射频空气等离子体中，通过铁氧体电镀在其上成功地沉积了磁铁矿(Fe3O4)涂层，通过暴露浸泡在H3BO3水溶液中的ePTFE薄膜表面，进一步提高了薄膜的润湿性，并成功地沉积了更细小的Fe3O4涂层。在犬体内实验表明，铁氧体涂层的ePTFE薄膜的生物相容性与未涂层的薄膜几乎相同。要揭示血管内皮细胞重组的增强作用，还需要进一步的实验。

Basic knowledges required for fabricating artificial blood vessel with ferrite coating on their inner wall were investigated ; the leakage flux from the ferrite coating is expected to enhance the endothelial reorganization, and, therefore, supress thrombi. Sheets of expanded polytetrafluoroethylene (EPTFE) membrane were exposed to an rf air plasma on which magnetite (Fe_3O_4) coating was successfully deposited by ferrite plating ; the rf plasma increases the wettability of the surface of the EPTFE.By exposing the surface of the EPTFE sheet which is dipped in an aqueous solution of H_3BO_3, the wettability was increased further more, and Fe_3O_4 coating of finer grains were successfully deposited. By in viva experiments on dogs revealed that the biocompatibility of the ferrite-coated EPTFE sheets are nearly equal to that of the uncoated sheets. To reveal the enhancement of the endothelial reorganization effect, further experiments are needed.