The function of the ribbon structure of the Golgi apparatus in vertebrates

该项目的目的是确定高尔基带结构在更高级别的细胞功能中的功能，包括培养细胞和整个生物体中的新陈代谢、细胞周期和细胞极性。对高尔基体功能的了解仅限于糖基化和膜转运的调节。然而，现在人们认识到高尔基体参与了高等生物体中一系列细胞网络的连接，如细胞极化、定向迁移、新陈代谢和自噬。脊椎动物已经进化出将单个高尔基体连接成带状结构的机制。这种带状结构的相关性仍然是一个谜。该项目旨在回答细胞生物学中的这个主要问题。

The aim of the project is to determine the function of the Golgi ribbon structure in higher order cell functions, including metabolism, cell cycle, and cell polarity in both cultured cells and whole organisms. Understanding of the functions of the Golgi has been restricted to the regulation of glycosylation and membrane transport. However, it is now recognised that the Golgi apparatus feeds into the wiring of a range of cellular networks in higher organisms such as cell polarisation, directed migration, metabolism and autophagy. Vertebrates have evolved mechanisms for joining individual Golgi stacks into a ribbon structure. The relevance of this ribbon structure remains a mystery. The project aims to answer this major question in cell biology.