The new mechanism in the development of polycystic kidney～the role of PTEN and EGF receptor in the proximal tubule～

多囊肾的发病机制尚不清楚。我们建立了近曲小管特异性PTEN基因敲除小鼠，发现了多囊肾的发生。我们观察了近曲小管的增殖和凋亡，发现增殖可能是囊肿形成的主要因素。我们还检查了纤毛，纤毛的数量和长度与对照小鼠没有差异。为了阐明EGF受体在囊肿形成中的作用，我们开始在近端小管中建立PTEN-EGF受体双敲除小鼠。现在，我们正在选择有效的路线，以发展双重淘汰。

The mechanism in the development of polycystic kidney is still unclear. We developed the proximal tubule specific PTEN knockout mice and found the development of polycystic kidney. We investigated the proliferation and apoptosis in the proximal tubule and the proliferation can be the main factor of the cyst formation. We also checked the cilia and the number and the length of the cilia were not different from control mice. To clarify the role of the EGF receptor in the cyst formation, we started to establish PTEN-EGF receptor double knockout mice in the proximal tubule. Now, we are choosing the effective line to develop the double knockout.