Molecular mechanisms underlying the kinetochore localization of Bub1

Bub1是一种保守的激酶，在染色体的忠实分离中发挥作用。Bub1定位于M期的动粒，这种动粒定位对其功能至关重要。然而，Bub1的动粒定位的潜在机制在很大程度上仍然未知。在这项研究中，我们发现，另一个保守的激酶Mps1磷酸化的动粒蛋白Spc7。这种磷酸化促进Bub1和Spc7之间的相互作用，导致Bub1的动粒定位。

Bub1 is a conserved kinase which has roles in faithful chromosome segregation. Bub1 localizes at kinetochores in M-phase and this kinetochore localization is essential for its function. However the mechanisms underlying the kinetochore localization of Bub1 remained largely unknown. In this study, we showed that another conserved kinase Mps1 phosphorylates the kinetochore protein Spc7. This phosphorylation promotes the interaction between Bub1 and Spc7, resulting in the kinetochore localization of Bub1.