Regulatory mechanism of EGF Receptor endocytosis by membrane deformingprotein FCHO2

内吞作用在EGF受体的信号转导、降解和再循环中起着至关重要的作用。因此阐明胞吞作用的基本过程是很重要的。我们研究了含F-BAR结构域蛋白FCHO2调控内吞作用的分子机制，最近发现其在激活泛素连接酶Nedd4L中的作用。我们研究了接头分子ARRDC1参与FCHO2/Nedd4L介导的胞饮过程，发现Nedd4L在质膜上的定位是其激活所必需的，是由ARRDC1和FCHO2共同调控的。

Endocytosis plays a critical role in the signal transduction,degradation, and recycling of EGF receptor. It is thus important to elucidate the basicprocess of endocytosis. We have studied the molecular mechanisms of F-BAR domaincontaining protein FCHO2 in the regulation of endocytosis and recently found its rolein the activation of ubiqutin ligase Nedd4L. Here we studied about the involvement ofadaptor molecule ARRDC1 in the FCHO2/Nedd4L mediated endocytosis process and revealedthat the localization of Nedd4L on plasma membrane, which is essential for its activation, is regulated by ARRDC1 and FCHO2 cooperatively.