Conservation and Analyzes of Genetic Information of Asian Ethnic Groups

本研究的目的是以细胞库和DNA库的形式保存亚洲少数民族特别是小群体的遗传信息。为此，我们在印度尼西亚、马来西亚和泰国进行了实地研究。野外研究：在种群遗传研究中，收集了来自桑班纳、帝汶、莫肯和马尼的标本。共收集标本400份，建立细胞系250株。基因组多样性研究：研究了这些人群与其他亚洲和大洋洲人群中SDF1、MC1R、aimand p53基因的多态性。疟疾相关基因：在存在寄生虫病数据的情况下，研究了3蛋白基因27 bp缺失和G6PD缺乏症在Sumbanese人中的流行情况。eb病毒相关外周t细胞增生性疾病：建立了一种快速灵敏的血浆DNA检测方法。

The aim of this study is to conserve genetic information of Asian ethnic groups especially small sized populations in the form of a cell bank and DNA bank. For this, we have conducted field studies in Indonesia, Malaysia and Thailand.1. Field study: for the population genetic study, specimens were collected from Sumbanese, Timorese, Moken and Mani. A total of 400 specimens were collected and 250 cell lines were established.2. Study on Genome diversity: Polymorphisms of the following genes, SDF1, MC1R, AIMland p53, were studied among these populations with other Asian and Oceanian populations.3. Malaria related genes: Prevalence of 27-bp deletion of the 3 protein gene arid G6PD deficiency was studied in Sumbanese in the presence of the parasitemia data.4. Epstein-Barr virus associated peripheral T-cell proliferative diseaseis: A rapid and sensitive plasma DNA test for this disease entity was established.