ANXIETY STUDY BY USING HGF TRANSGENICMICE

背景：肝细胞生长因子(HGF)具有选择性地引导丘脑皮质投射到中间靶点苍白球，并最终到达其最终皮质目的地的能力。HGF可能在焦虑的调节中起作用。对HGF的其他中枢行为影响知之甚少。目的：研究肝细胞生长因子(HGF)对大鼠焦虑的影响。方法：将HGF恒速注入大鼠侧脑室，观察其对焦虑的影响。结果：在高架迷宫试验和黑白盒试验中，HGF使焦虑的各项指标均增加。未观察到对一般运动活动的显著影响。结论：HGF脑内注射具有抗焦虑作用。

BACKGROUND : Hepatocyte growth factor(HGF) has the capacity to selectively direct thalamocortical projections into an intermediate target, the pallidum, and eventually to their final cortical destination. HGF may have a role in the mediation of anxiety. Very little is known about other central behavioral effects of HGF. OBJECTIVE : Our aim was to determine what effect HGF has on anxiety in rats. METHODS : HGF was infused at a constant rate into cerebral lateral ventricles and its effect on anxiety in rats was monitored. RESULTS : In the elevated plus maze test and the black and white box test, HGF administration caused all indicators of anxiety to increase. No significant effect on general locomotor activity was seen. CONCLUSION : HGF infusion into the brain produces an anxiolytic effect.