The development and a clinical application of new imaging technique for epileptic focus using DAIM and tensor MRL

（1）锰离子具有顺磁性，对锰离子周围的水具有缩短弛豫时间的作用。而神经元激活时，锰离子代替钙离子被神经元摄取。因此，锰离子是磁共振成像的有效信号增强剂，可以清楚地显示大脑皮层的激活区域，因此称为活性诱导锰依赖对比磁共振成像（AIM-MRI）。我制作了新的成像系统，利用AIM显示癫痫的激活灶。(1)I给大鼠注射海人酸后，观察大鼠行为学及脑MRI。结果发现，海人酸注射液可造成癫痫模型。(2)In在AIM-MRI实验中，通过阻断血脑屏障后维持血压来控制脑水肿。然后我成功地控制了由脑水肿引起的异常失活。(3)I采用高浓度丙泊酚和低浓度异氟醚或α-氯醛糖优化麻醉。2.提出了一种新的成像技术，即在脑电中出现较大波时，水分子的迁移沿着离子的迁移进入细胞，利用弥散张量磁共振成像（DTI-MRI）进行成像。（1）DTI-MRI在磁场梯度脉冲的涡流作用下产生形变。在同一层位上，采用自旋回波法，将DTI-MRI与T1加权磁共振图像相匹配。(2)I发现DTI-MRI的各向异性分数是估计脑纤维方向的定量值。(3)梯度脉冲在脑电图中引起噪声。我没有足够的时间或金钱来通过在梯度脉冲的安静期间调整脑电图的采样时间或安装新的具有宽动态范围的模数转换器来从梯度脉冲噪声中提取脑电图来降低噪声。

(1)Manganese ion is paramagnetism and has effect to shorten the relaxation time of water around manganese ion. Whereas, manganese ion uptake to the neuron instead of Calcium ion when the neuron is activated. So that manganese ion is the useful signal enhance compounds for MRI to make clear the activated area on cortex, so call the activity induced manganese-dependent contrast MRI(AIM-MRI). I made the new imaging system to present the activation focus of epilepsy using AIM. (1)I observed the behavior and MRI of brain of rats after injection kanic acid to rats. I found that the injection of kainic acid made the model of epilepsy. (2)In the experiment AIM-MRI, I controlled the brain edema by keeping blood pressure after the brake the blood-brain barrier. Then I succeeded to control abnomal de-activation by the brain edema. (3)I optimized the anesthesia using high concentration propofol and low isoflurane or alpha-chloralose. 2.I made a new image technique of transfer of water molecule coming along with ion transfer into cells using diffusion tensor magnetic resonance imaging (DTI-MRI) when the large wave was found in the electroencephalography. (1)DTI-MRI were deformation by the eddy current of the magnetic field gradient pulses. I modified DTI-MRI matched to T1 weighted magnetic resonance image uging spin echo method at same slice position. (2)I found the fractional anisotropy in DTI-MRI is quantitative value to estimate brain fiber direction. (3) The gradient pulse induced the noise in the electroencephalography. I do not have enough time or money to reduce the noise by adjust the sampling time of the electroencephalography during quiet duration of gradient pulse or installing the new analogue digital converter with wide dynamic range to pick up the electroencephalography from the gradient pulse noise.