Research on the reevaluation of effectiveness in recipients of influenza vaccines

在大坂府K市的一家儿科诊所，156名1-5岁的儿童接受了2剂流感疫苗，其中53名接受者入组本研究。在53名接种者中，有21名儿童经快速检测确诊为流感。21例患者中，A型和B型各5例。对从患者中分离的疫苗株和自体病毒进行了急性期血清的血凝抑制试验和微量中和试验。对疫苗株，所有患者HI和NT均阳性，HI> 40者9例，NT> 40者8例，NT> 20者2例。而对自体病毒，4例患者HI滴度超过40，4例患者低于10。仅1例患者显示NT滴度为20，其他患者均低于10。这些结果表明，在接种者中，流感的患病将更多地与NT滴度而不是HI滴度相关。

In a pediatric clinic at K city in Osaka prefecture, 156 children aged 1-5 year old received 2 doses of an influenza vaccine, and of them 53 recipients were enrolled in this study. Of 53 vaccinees, 21 children suffered from influenza diagnosed by rapid test. Of 21 patients A or B type influenza viruses were isolated from 5 patients, respectively. Hemagglutination inhibition assay and microneutralisation assay of acute phase sera were performed against both vaccine strains and autologous viruses which were isolated from the patients. To vaccine strains all patients showed positive HI and NT and 9 out of 10 patients were over 40 HI and 8 out of 10 patients showed NT over 40, 2 were NT 20. On the contrary, to the autologous virus 4 patients showed HI titer over 40 and 4 patients were below 10. Only one patient showed NT titer of 20, and the others were below 10. These findings suggest that in the vaccinees the suffering from influenza would be more associated with NT titer rather than HI titer.