Three-dimensional analysis of trabecular bone structure of human vertebra in vivo using multi-detector row computed tomography-cross sectional and longitudinal studies-

我们开发了一个系统来执行三维（3D）分析人的椎骨小梁骨结构在体内使用多探测器行计算机断层扫描（MDCT）。目的是评估三维结构参数是否可以评估骨的易碎性。我们研究了20名无椎体骨折的女性（67±8岁）和27名有椎体骨折的女性（74±7岁）。他们接受了MDCT和双x线吸收仪（DXA）腰椎检查。计算了以下三维参数；骨小梁体积分数（BV/TV），骨小梁厚度(Tb。Th)，小梁数（Tb）。N)，小梁分离(Tb。Sp)、骨小梁模式因子（TBPf）、结构模型指数（SMI）和分形维数（FD）。采用线性回归分析评价结构参数与骨密度之间的相关性，采用学生t检验评价有无椎体骨折女性的区别。BMD与BV/TV、. tb值显著相关。Sp、TBPf、SMI和FD的相关系数分别为0.30、0.32、-0.46、-0.44和0.36。两组TBPf、SMI、FD值差异有统计学意义，t值分别为2.6、3.2、2.4，而L3 BMD值差异无统计学意义。结果提示骨小梁结构与骨密度相关，骨小梁结构分析可以评价骨脆性横截面。我们对相同的受试者进行了四年的长期评估，但这些参数没有显著变化。

We developed a system to perform three-dimensional(3D) analysis of trabecular bone structure of human vertebra in vivo using multi-detector row computed tomography(MDCT). The purpos was to evaluate whether 3D structural parameters can evaluate fragility of bone. We studied 20 women with no vertebral fractures(67±8 years old) and 27 women with vertebral fractures(74±7 years old). They underwent lumbar examinations by MDCT and dual x-ray absorptiometry(DXA). The' following 3D parameters were calculated ; trabecular bone volume fraction(BV/TV), trabecular thickness(Tb.Th), trabecular number(Tb.N), trabecular separation(Tb.Sp), trabecular bone pattern factor(TBPf), structure model index(SMI), and Fractal dimension(FD). Correlation between structural parameters and BMD was evaluated by linear regression analysis, and discrimination between women with and without vertebral fractures was evaluated by student t' test. The BMD was significantly correlated with the values of BV/TV,.Tb.Sp, TBPf, SMI and FD with correlation coefficients of 0.30,0.32,-0.46,-0.44 and 0.36,respectively. The values of TBPf, SMI and FD significantly differed between the two groups with t-values of 2.6,3.2,and 2.4,respectively, but the L3 BMD did not differ. The results suggested that trabecular bone structure correlated with BMD and that the trabecular bone structural analysis could evaluate bone fragility cross-sectionlay. We evaluated the same subjects londitudinaly for four years, but these parameters did not change significantly.