Life-style related risk factors for ovarian and endometrial cancer in a case-control study

由于环境因素可能在卵巢癌和子宫内膜癌的病因学中起作用，因此，2003年至2005年在日本北海道进行了一项以医院为基础的病例对照研究，以评估与卵巢癌或子宫内膜癌相关的一些环境和其他危险因素。首先，我们分析了来自札幌医科大学医院的71例上皮性卵巢癌患者和从病例所在地区的居民登记处选择的269例对照者的数据。在控制了年龄和地点后，观察到卵巢癌的风险显著增加与经常食用米饭（趋势，P = 0.0248）以及牛肉和/或猪肉（趋势，P = 0.0259）有关。A显著降低的风险与更高的体力活动频率相关（趋势，P = 0.00320）。妊娠次数（趋势，P = 0.0371）和活产次数（趋势， ...更多信息 ，P = 0.0180）。这项研究提供了额外的发现，建议的危险因素与卵巢癌的风险在日本。其次，我们分析了124例子宫内膜癌和269例对照组的数据没有任何癌症。在控制了潜在混杂因素的影响后，经常食用油炸豆腐（P = 0.033）、卷心菜（P = 0.018）、其他白色蔬菜（P = 0.037）和饮酒习惯（P = 0.033）与子宫内膜癌风险降低显著相关。体力活动的频率和持续时间显著降低危险性（P <0.05）。体重和体重指数（BMI，P <0.01）、最重体重时最重非妊娠体重和BMI（P <0.01）、20年以来最大体重增加（P <0.001）均与子宫内膜癌风险增加相关。妊娠次数（P <0.01）和活产次数（P <0.001）的风险呈显著下降趋势。服用口服避孕药的经验与子宫内膜癌的风险降低显著相关（P = 0.038）。母亲或姐妹的子宫内膜癌病史与子宫内膜癌风险增加显著相关（P = 0.041）。通过增加体力活动避免肥胖可能是子宫内膜癌一级预防的实用手段。少

Because it has been suggested that environmental factors may play a role in the etiology of ovarian cancer and, endometrial cancer, a hospital-based case-control study was conducted to assess some environmental and other risk factors associated with ovarian or endometrial cancer from 2003 to 2005 in Hokkaido Japan. Firstly, we analyzed the data of 71 cases with epithelial ovarian cancer from the Sapporo Medical University Hospital and 269 controls selected from the residential registries in areas same to those of the cases. After controlling for age and location, a significantly increased risk of ovarian cancer was observed to be associated with frequent consumption of rice (trend, P=0.0248), as well as beef and/or pork (trend, P=0.0259). A Significantly decreased risk was associated with higher frequency of physical activity (trend, P=0.00320). Trends in relation to a significant decrease in risk were obtained as number of pregnancies (trend, P=0.0371) and number of live births (trend … More , P=0.0180). This study provides additional findings on the association of suggested risk factors with risk of ovarian cancer in Japan.Secondly, we analyzed the data of 124 cases with endometrial cancer and 269 controls without any cancer. After controlling for the effect of potential confounders, frequent consumption of fried soybean curd (P=0.033), cabbage (P=0.018), other white vegetables (P=0.037), and alcohol drinking habits (P=0.033) was significantly associated with the decreased risk of endometrial cancer. Significantly decreased risks were noted for frequencies or duration of physical activities (P<0.05). Body weight and body mass index (BMI, P<0.01), heaviest non-pregnant body weight and BMI at the time of heaviest body weight (P<0.01), and maximum weight gain since 20 years (P<0.001) were all associated with the increased risk of endometrial cancer. Significantly decreased trends for risk were obtained for the number of pregnancies (P<0.01) and the number of livebirths (P<0.001). The experience in taking oral contraceptives was significantly associated with the reduced risk of endometrial cancer (P=0.038). A history of endometrial cancer in a mother or sister was significantly associated with the increased risk of endometrial cancer (P=0.041). An avoidance of obesity through increase in physical activities may be a practical means for primary prevention of endometrial cancer. Less