400 MHz NMR-Spektrometer

该应用程序是用于处理溶液中相应5mm核磁共振样品的常规操作的400 MHz核磁共振光谱仪。用于z梯度和自动调谐的主探头必须是宽带可调谐的（至少在包括核心31P和199Hg以及17O和109Ag的共振频率范围内）。为了能够以高灵敏度测量13C（特别是在频繁的情况下，在季碳的TUC）和不太敏感的异质核（特别是在主要的杂环体系中的15N），宽带线圈应该在里面。外线圈应设计为1H和19F，并使两个磁芯（也同时）去耦。氘预计将作为锁芯。测量还应能够在高达150°c的温度下进行。配备60个位置的自动取样器应尽可能确保昼夜连续工作。为了能够进行短的，选定的二维测量（例如1H， 1H- cozy和1H， 13C-HSQC）除了大约。每年6000个质子测量，另外还有大约。15000碳基光谱，非均匀采样（NUS），包括相应的处理。

The application is for a 400 MHz NMR spectrometer for routine operation for processing corresponding 5mm NMR samples in solution. The main probe head to be used with Z-gradient and automatic tuning must be broadband tunable (at least in the ranges including the resonance frequencies of the cores 31P and 199Hg as well as 17O and 109Ag). In order to be able to measure with high sensitivity 13C (especially in the frequent case at the TUC of quaternary carbons) and less sensitive hetero nuclei (especially 15N in mainly heterocyclic systems), the broadband coil should be inside. The outer coil should be designed for 1H and 19F and enable the (also simultaneous) decoupling of both cores. Deuterium is to be anticipated as the core for the lock. Measurements should also be able to be carried out at a temperature of up to 150 ° C. An auto sampler with 60 places is supposed to ensure continuous operation day and night as far as possible. In order to be able to carry out short, selected 2D measurements (e.g. 1H, 1H-COZY and 1H, 13C-HSQC) in addition to approx. 6000 proton measurements per year and an additional approx. 15000 carbon-based spectra, non-uniform sampling ( NUS) including the corresponding processing.